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      Tissue-engineered blood vessel substitute by reconstruction of endothelium using mesenchymal stem cells induced by platelet growth factors.

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          Abstract

          Cardiovascular diseases remain leaders as the major causes of mortality in Western society. Restoration of the circulation through construction of bypass surgical treatment is regarded as the gold standard treatment of peripheral vascular diseases, and grafts are necessary for this purpose. The great saphenous vein is often not available and synthetic grafts have their limitations. Therefore, new techniques to produce alternative grafts have been developed and, in this sense, tissue engineering is a promising alternative to provide biocompatible grafts. This study objective was to reconstruct the endothelium layer of decellularized vein scaffolds, using mesenchymal stem cells (MSCs) and growth factors obtained from platelets.

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          Author and article information

          Journal
          J. Vasc. Surg.
          Journal of vascular surgery
          Elsevier BV
          1097-6809
          0741-5214
          Jun 2014
          : 59
          : 6
          Affiliations
          [1 ] Department of Surgery and Orthopedics, Vascular Laboratory, Botucatu Medical School, UNESP-Paulista State University, Botucatu, Brazil; Cell Engineering Laboratory, Blood Transfusion Center, Botucatu Medical School, UNESP-Paulista State University, Botucatu, Brazil. Electronic address: matheus.fameca@ig.com.br.
          [2 ] Cell Engineering Laboratory, Blood Transfusion Center, Botucatu Medical School, UNESP-Paulista State University, Botucatu, Brazil; Department of Morphology, Extracellular Matrix Laboratory, Botucatu Biosciences Institute, UNESP-Paulista State University, Botucatu, Brazil.
          [3 ] Cell Engineering Laboratory, Blood Transfusion Center, Botucatu Medical School, UNESP-Paulista State University, Botucatu, Brazil.
          [4 ] Department of Surgery and Orthopedics, Vascular Laboratory, Botucatu Medical School, UNESP-Paulista State University, Botucatu, Brazil.
          [5 ] Department of Pathology, Botucatu Medical School, UNESP-Paulista State University, Botucatu, Brazil.
          [6 ] Cell Engineering Laboratory, Blood Transfusion Center, Botucatu Medical School, UNESP-Paulista State University, Botucatu, Brazil; Department of Urology, Botucatu Medical School, UNESP-Paulista State University, Botucatu, Brazil.
          Article
          S0741-5214(13)00973-7
          10.1016/j.jvs.2013.05.032
          23830317
          085b30cf-5a8a-4cb1-8aa8-10ffaa259c81
          History

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