Pre- and Postcholecystectomy Duodenogastric Reflux

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Abstract

The purpose of the study was to assess whether cholecystectomy is usually followed by increased duodenogastric reflux and whether there are subsequent changes in the histology of the gastric mucosa and in acid secretion. Eleven patients were submitted, before cholecystectomy and 6 months afterwards, to gastric aspirates, assay of bile acids in the gastric juice and gastroscopy with biopsies from the antral mucosa and the main body. Our results show a significant increase, after cholecystectomy, in the amount of duodenogastric reflux (p < 0.01). However, the total amount of bile acids present in the stomach do not seem to affect the inflammatory injury to the mucosa. Nine times out of eleven there was a reduction of maximal gastric acid output: again, this fact does not seem to be correlated to the amount of bile reflux. The authors conclude that, as already stressed by others, injury to the mucosa is less affected by the amount of bile acids flowing back into the stomach than by other important factors such as the duration of contact, gastric pH, the presence of other constituents in the duodenal juice (lysolecithin) and the type of bile acid that is actually present.

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Author and article information

Journal

Journal ID (publisher-id): DSU

Journal ID (nlm-ta): Dig Surg

Journal ID (doi): 10.1159/issn.0253-4886

Title: Digestive Surgery

Publisher: S. Karger AG

ISSN (Print): 0253-4886

ISSN (Electronic): 1421-9883

Publication date Subscription-year: 1986

Publication date (Print): 1986

Publication date (Electronic): 05 November 2008

Volume: 3

Issue: 4

Pages: 305-310

Affiliations

^aDivision of Surgery, ^bLaboratory of Clinical Chemistry, ^cDepartment of Digestive Physiopathology, ^dDepartment of Endoscopy, and ^eDepartment of Histopathology, Istituto di Ricovero e Cura a Carattere Scientifico, Castellana Grotte, Bari, Italy

Article

Publisher ID: 171752 Other ID: Dig Surg 1986;3:305–310

DOI: 10.1159/000171752

SO-VID: 08828756-f617-45ca-9546-362fc300c88d

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 18 June 1986

Date accepted : 15 July 1986

Page count

Pages: 6

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