Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial.

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Abstract

Glutamate excitotoxicity might contribute to the pathophysiology of amyotrophic lateral sclerosis. In animal models, decreased excitatory aminoacid transporter 2 (EAAT2) overexpression delays disease onset and prolongs survival, and ceftriaxone increases EAAT2 activity. We aimed to assess the safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis in a combined phase 1, 2, and 3 clinical trial.

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Journal

Journal ID (iso-abbrev): Lancet Neurol

Title: The Lancet. Neurology

ISSN (Electronic): 1474-4465

ISSN (Print): 1474-4422

Publication date (Electronic): Nov 2014

Volume: 13

Issue: 11

Affiliations

[1 ] Massachusetts General Hospital, Boston, MA, USA. Electronic address: mcudkowicz@partners.org.

[2 ] Massachusetts General Hospital, Boston, MA, USA.

[3 ] Carolinas Medical Centre, Charlotte, NC, USA.

[4 ] National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.

[5 ] Tufts University School of Medicine, Boston, MA, USA.

[6 ] Eliot Health System, Manchester, NH, USA.

[7 ] Ohio State University, Columbus, OH, USA.

[8 ] California Pacific Medical Center, San Francisco, CA, USA.

[9 ] University of California-San Francisco, Fresno, CA, USA.

[10 ] Johns Hopkins University, Baltimore, MD, USA.

[11 ] Methodist Hospital, Houston, TX, USA.

[12 ] Sunnybrook Health Science Centre, Toronto, ON, Canada.

[13 ] State University of New York, Upstate Medical University, Syracuse, NY, USA.

Article

Publisher Item ID: S1474-4422(14)70222-4 Mid ID: NIHMS635313

DOI: 10.1016/S1474-4422(14)70222-4

PubMed ID: 25297012

SO-VID: 08c03bab-8dbb-43d0-9242-cb9188ad760a

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