- Record: found
- Abstract: not found
- Article: not found
Simultaneous assay of ephedrine hydrochloride, theophylline, papaverine hydrochloride and hydroxyzine hydrochloride in tablets using RP-LC
October 1999
October 1999
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
The analytical problem was to control the quality of imported antiasthmatic tablets
containing ephedrine hydrochloride, theophylline, papaverine hydrochloride and hydroxyzine
hydrochloride. The aim of the analytical method for the assay was to separate, identify
and quantify all compounds, at the same time. A gradient capable RP-LC system was
used, using a commercially packed Nucleosil C18 column connected to a dual channel
variable, programmable wavelength detector. The analysis was performed in the gradient
program of increasing concentration of acetonitrile in water. The influence of pH
of the mobile phase was established. The proposed method is reliable, reproducible,
easy to perform and satisfies the aim.