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      Systematic review and meta-analysis of randomized controlled trials on Wenxin keli

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          Abstract

          Objective

          The aim of the study was to evaluate the effectiveness, safety, and cost associated with Wenxin keli in the treatment of cardiovascular diseases based on meta-analysis.

          Methods

          The terms “Wenxin keli” and “Wenxin” were used as the search terms in the PubMed, ProQuest, Springer, the Cochrane Library, CNKI (China National Knowledge Infrastructure), VIP (Chinese Scientific Journals Database), and Wan fang electronic databases (from January 2000 to October 2015). Relevant print journals and conference papers were also searched. Studies on randomized controlled trials (RCTs) of Wenxin keli used in the treatment of cardiovascular diseases were screened, and its indications were classified. Meta-analysis of these studies was conducted using the RevMan 5.2 software.

          Results

          A total of 49 RCTs (n=4,610) were included, 29 of which focused on arrhythmia, seven on angina, seven on heart failure, two on viral myocarditis, and four on menopausal syndrome. Analysis of the therapeutic indications of Wenxin keli showed that it was comparatively more curative and effective than other available treatments for cardiovascular diseases.

          Conclusion

          Wenxin keli showed better clinical efficacy in the treatment of arrhythmia, angina, and heart failure; however, more high-quality evidence is needed to support its use in the clinical setting.

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          Most cited references 56

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          Global Status Report on noncummunicable diseases 2010

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            Curative effect analysis of wenxinkeli in treatment of cardiac arrhythmia

             J. Liu,  Levy Cao,  Y. Z. GE (2009)
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              Effect of Wenxin Granule on chronic heart failure

               JH Hu (2010)
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                Author and article information

                Journal
                Drug Des Devel Ther
                Drug Des Devel Ther
                Drug Design, Development and Therapy
                Drug Design, Development and Therapy
                Dove Medical Press
                1177-8881
                2016
                14 November 2016
                : 10
                : 3725-3736
                Affiliations
                School of Management, Beijing University of Chinese Medicine, Beijing, People’s Republic of China
                Author notes
                Correspondence: Wentao Zhu, School of Management, Beijing University of Chinese Medicine, No 11, Beijing North Third Ring Road, Chaoyang, Beijing, People’s Republic of China, Tel +86 10 6428 6475, Fax +86 10 6428 6475, Email zhuwt@ 123456bucm.edu.cn
                Article
                dddt-10-3725
                10.2147/DDDT.S112333
                5115693
                © 2016 Wang et al. This work is published and licensed by Dove Medical Press Limited

                The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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