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      Terpenoids and bisbibenzyls from Chinese liverworts Conocephalum conicum and Dumortiera hirsuta.

      Journal of Asian natural products research
      Bibenzyls, chemistry, isolation & purification, China, Hepatophyta, Molecular Structure, Terpenes

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          Abstract

          Four new monoterpene esters, 2alpha,5beta-dihydroxybornane-2-cinnamate (1), 2alpha,5beta-dihydroxybornane-5-acetyl-2-cinnamate (2), 2alpha,5beta-dihydroxybornane-2-p-hydroxycinnamate (3) and 2alpha,5beta-dihydroxy-bornane-2-cis-p-hydroxycinnamate (4), together with a known compound 3,4-dimethoxystyrene (5) were isolated from Chinese liverwort Conocephalum conicum and six known compounds, 5,7-dihydroxycalamenene (6), 7-hydroxycalamenene (7), lunularin (8), riccardin C (9), marchantin C (10) and riccardin D (11) were isolated from Dumortiera hirsuta. Their structures were elucidated by extensive spectral analysis and chemical correlations. Compounds 1 and 8 showed moderate cytotoxicity against human HepG2 cells with IC50 4.5 microg/ml and 7.4 microg/ml, respectively, while compound 8 also showed antimicrobacterial activity against Pseudomonas aeruginosa with minimum inhibitory concentration at 64 microg/ml.

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          Author and article information

          Journal
          16753803
          10.1080/1028602042000325537

          Chemistry
          Bibenzyls,chemistry,isolation & purification,China,Hepatophyta,Molecular Structure,Terpenes
          Chemistry
          Bibenzyls, chemistry, isolation & purification, China, Hepatophyta, Molecular Structure, Terpenes

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