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      Influencia de la microbiota intestinal en la enfermedad hepática crónica. Su rol en el hepatocarcinoma Translated title: Microbiota intestinal their influence on chronic liver disease. Role in hepatocellular carcinoma

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          Abstract

          El incremento de la traslocación de bacterias intestinales es característico en pacientes con enfermedad hepática crónica y favorece la inflamación y la fibrosis del hígado.1-3 Se ha implicado a la microbiota intestinal en la patogénesis y progresión de enfermedades hepáticas como Enfermedad Grasa Hepática No alcohólica, Esteatohepatitis no alcohólica, Colangitis Esclerosante Primaria, Enfermedad hepática por Falla intestinal y el Hepatocarcinoma. Numerosas investigaciones al respecto, vienen señalando que la microbiota intestinal y los receptores tipo Toll (TLRs) promueven el Hepatocarcinoma (HCC).1,4 La Hepatocarcinogenesis involucra a los TLR4 y a la microbiota intestinal, pero estos, no son requeridos para la iniciación del HCC sino para su promoción, mediante el incremento de la proliferación, expresión de la epiregulina hepatomitogena y la prevención de la apoptosis.4,5 La esterilización del intestino en etapas tardías de la hepatocarcinogenesis , previenen el HCC , por lo que de allí se desprenden que tanto la microbiota como estos receptores tipo Toll, representan blancos terapéuticos para la prevención del HCC en pacientes con enfermedad hepática crónica avanzada.4-6

          Translated abstract

          The increase of the translocation of intestinal bacteria is characteristic of patients with chronic liver disease and promotes inflammation and fibrosis of the liver.1-3 Has been involved in the intestinal microbiota in the pathogenesis and progression of liver diseases such as liver disease Fat Non-alcoholic, non-alcoholic steatohepatitis, Primary sclerosing cholangitis, liver disease by intestinal failure and hepatocellular carcinoma. Numerous investigations into the matter, come by noting that the intestinal microbiota and the toll-like receptors (TLRs) promote the Hepatocellular carcinoma (HCC).1-4 The Hepatocarcinogenesis involves TLR4 and the intestinal microbiota, but these, are not required for the initiation of the HCC but for their promotion, through the increase of the proliferation, expression of the epiregulina hepatomitogena and the prevention of apoptosis.4-6

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          Targeting gut flora to hepatocellular carcinoma

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            Targeting gut flora to hepatocellular carcinoma

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              Author and article information

              Contributors
              Role: ND
              Journal
              gen
              Gen
              Gen
              Sociedad Venezolana de Gastroentereología
              2477-975X
              June 2016
              : 70
              : 2
              : 064-069
              Affiliations
              [1 ] Universidad del Zulia Venezuela
              Article
              S0016-35032016000200006
              09ec3f81-e929-4137-adba-bedf62e5d3f8

              http://creativecommons.org/licenses/by/4.0/

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              SciELO Venezuela

              Self URI (journal page): http://www.scielo.org.ve/scielo.php?script=sci_serial&pid=0016-3503&lng=en

              hiperlipasemia,enfermedad celíaca,hipe-renzinemia benigna familiar,liver cirrhosis,microbiota,hepatocellular carcinoma,Toll-like receptors

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