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      Discovery and clinical translation of novel glaucoma biomarkers

      , , , ,

      Progress in Retinal and Eye Research

      Elsevier BV

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          Split-spectrum amplitude-decorrelation angiography with optical coherence tomography

          Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction. To overcome this limitation, we developed split-spectrum amplitude-decorrelation angiography (SSADA) to improve the signal-to-noise ratio (SNR) of flow detection. The full OCT spectrum was split into several narrower bands. Inter-B-scan decorrelation was computed using the spectral bands separately and then averaged. The SSADA algorithm was tested on in vivo images of the human macula and optic nerve head. It significantly improved both SNR for flow detection and connectivity of microvascular network when compared to other amplitude-decorrelation algorithms.
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            Biomarkers and surrogate endpoints: preferred definitions and conceptual framework.

              (2001)
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              Optical coherence tomography angiography of optic disc perfusion in glaucoma.

              To compare optic disc perfusion between normal subjects and subjects with glaucoma using optical coherence tomography (OCT) angiography and to detect optic disc perfusion changes in glaucoma.
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                Author and article information

                Journal
                Progress in Retinal and Eye Research
                Progress in Retinal and Eye Research
                Elsevier BV
                13509462
                January 2021
                January 2021
                : 80
                : 100875
                Article
                10.1016/j.preteyeres.2020.100875
                © 2021

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