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      Seven years’ experience with alendronate in postmenopausal Japanese women with osteoporosis

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          Abstract

          A retrospective study was performed to evaluate the outcome of alendronate (ALN) treatment for seven years in postmenopausal Japanese women with osteoporosis. Forty-seven postmenopausal women with osteoporosis (mean age at baseline 65.7 years) treated with ALN for over seven years in our outpatient clinic were analyzed. Lumbar spine bone mineral density (BMD) was measured using dual energy X-ray absorptiometry, and urinary levels of cross-linked N-terminal telopeptides of type I collagen (NTX) and serum alkaline phosphatase (ALP) were monitored during the seven-year treatment period. Urinary NTX and serum ALP levels decreased (−48.2% at three months and −15.7% at seven years, respectively) and lumbar spine BMD increased (+12.8% at seven years) compared with baseline values. No serious adverse events were observed, including osteonecrosis of jaw, atypical femoral diaphysis fractures, or atrial fibrillation. To our knowledge, this is the first report of the outcome of ALN treatment for seven years in Japanese patients with osteoporosis. ALN successfully suppressed bone turnover and increased lumbar spine BMD from the baseline value over the course of the seven-year treatment period without causing any severe adverse events.

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          Author and article information

          Journal
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          2010
          2010
          26 April 2010
          : 6
          : 201-206
          Affiliations
          [1 ] Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
          [2 ] Department of Neurology, Mitate Hospital, Fukuoka, Japan
          [3 ] Department of Orthopaedic Surgery, Keiyu Orthopaedic Hospital, Gunma, Japan
          Author notes
          Correspondence: Jun Iwamoto, Institute for Integrated Sports Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan, Tel +81 3 3353 1211, Fax +81 3 3352 9467, Email jiwamoto@ 123456sc.itc.keio.ac.jp
          Article
          tcrm-6-201
          2861441
          20463781
          © 2010 Iwamoto et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          Categories
          Original Research

          Medicine

          alendronate, bone turnover, long-term treatment, bone mineral density, osteoporosis

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