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      Presence of ACTH-Potentiating Factors in Rat Anterior Pituitary Glands

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          High molecular weight ACTH fractions, obtained through gel filtration of boiled rat anterior pituitary extract, induced a marked increase in corticosterone production from isolated rat adrenal cells in the presence of low concentrations of ACTH-(1-24). This indicates the presence of heat-stable factors augmenting the steroidogenic action of ACTH in the rat anterior pituitary. We also noted that these factors potentiated the activity not only of ACTH-(1-24) but also of ACTH-(1–18). The ACTH-potentiating factors in rat anterior pituitary extract are possibly present in heterogeneous forms according to their molecular weights (8,000, 10,000 and 15,000), their mobility in ion-exchange chromatography and their content in RIA-ACTH activity. Of these three forms, the former comigrated with biological ACTH activity. The remaining two forms were free of it. Since the effect of potentiating factors on modified ACTH-(1–19), shown to be less susceptible to proteolytic degradation than ACTH-(l-24), was similar to the effect on ACTH-(1-24), it is suggested that potentiation was not due to an inhibition of ACTH proteolysis.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 14
          : 3
          : 155-164
          aSecond Department of Internal Medicine, Osaka University Medical School, Osaka; bDepartment of Internal Medicine, Itami Municipal Hospital, Hyogo, Japan
          179383 Horm Res 1981;14:155–164
          © 1981 S. Karger AG, Basel

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          Pages: 10
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