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      Is Open Access

      Unusual penile localization of melanoma

      case-report

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          Abstract

          Penile's melanoma is a rare situation, often associated with late diagnosis and high morbidity and mortality. We report the case of a 70‐year‐old man. He represented progressive skin lesions of the penile gland. A surgical biopsy with histopathological and immunohistochemical studies established the diagnosis of malignant melanoma of the penis in the metastatic stage. This case was managed by palliative immunotherapy and is currently under treatment by Pembrolizumab. Malignant melanoma of the penis represents an exceptional situation, in which only rapid diagnosis at an early stage allows treatment with optimal therapeutic results.

          Abstract

          Penile's melanoma is a serious disease whose diagnosis is often late because of its intimate location. We have to encourage our patients to consult a doctor quickly in the face of any skin lesion of the penis to be taken care of adequately.

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          Most cited references27

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          Cutaneous melanoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

          O. Michielin, A.C.J. van Akkooi, P.A. Ascierto … (2019)
          Article 0 comments Cited 208 times – based on 0 reviews     Review now
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            Recent trends in cutaneous melanoma incidence and death rates in the United States, 1992-2006.

            Ahmedin Jemal, Mona Saraiya, Pragna Patel … (2011)
            Increasing cutaneous melanoma incidence rates in the United States have been attributed to heightened detection of thin (≤ 1-mm) lesions. We sought to describe melanoma incidence and mortality trends in the 12 cancer registries covered by the Surveillance, Epidemiology, and End Results program and to estimate the contribution of thin lesions to melanoma mortality. We used joinpoint analysis of Surveillance, Epidemiology, and End Results incidence and mortality data from 1992 to 2006. During 1992 through 2006, melanoma incidence rates among non-Hispanic whites increased for all ages and tumor thicknesses. Death rates increased for older (>65 years) but not younger persons. Between 1998 to 1999 and 2004 to 2005, melanoma death rates associated with thin lesions increased and accounted for about 30% of the total melanoma deaths. Availability of long-term incidence data for 14% of the US population was a limitation. The continued increases in melanoma death rates for older persons and for thin lesions suggest that the increases may partly reflect increased ultraviolet radiation exposure. The substantial contribution of thin lesions to melanoma mortality underscores the importance of standard wide excision techniques and the need for molecular characterization of the lesions for aggressive forms. Copyright © 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
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              Malignant tumors of the penis.

              Kimberly L Brady, Mary Gail Mercurio, Marc D Brown (2013)
              Although penile cancer is rare in developed countries, it occurs more frequently in other parts of the world and causes significant morbidity and mortality.
              Article 0 comments Cited 19 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Mohamed Kaakoua:
                ORCID: https://orcid.org/0000-0002-7660-771X
                mohamedkaakoua.mk@gmail.com
                Journal
                Journal ID (nlm-ta): Clin Case Rep
                Journal ID (iso-abbrev): Clin Case Rep
                Journal ID (doi): 10.1002/(ISSN)2050-0904
                Journal ID (publisher-id): CCR3
                Title: Clinical Case Reports
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Electronic): 2050-0904
                Publication date (Electronic): 19 November 2022
                Publication date Collection: November 2022
                Volume: 10
                Issue: 11 ( doiID: 10.1002/ccr3.v10.11 )
                Electronic Location Identifier: e6500
                Affiliations
                [ 1 ] Medical Oncology Department Ibn Sina Military Hospital Marrakesh Morocco
                [ 2 ] Pathology Department Ibn Sina Military Hospital Marrakesh Morocco
                [ 3 ] Urology Department Ibn Sina Military Hospital Marrakesh Morocco
                [ 4 ] Medical Oncology Department Mohammed VI University Hospital Marrakesh Morocco
                Author notes
                [*] [* ] Correspondence

                Mohamed Kaakoua, Medical Oncology Ibn Sina Military Hospital, Faculty of Medicine and Pharmacy Mohamed VI, Caddy Ayyad University, Marrakesh, Morocco.

                Email: mohamedkaakoua.mk@ 123456gmail.com

                Author information
                https://orcid.org/0000-0002-7660-771X
                Article
                Publisher ID: CCR36500 Other ID: CCR3-2022-04-0918.R3
                DOI: 10.1002/ccr3.6500
                PMC ID: 9675376
                PubMed ID: 36415702
                SO-VID: 0bc3862f-a491-4edf-8c51-c35ea3f5f294
                Copyright © © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

                History
                Date revision received : 19 August 2022
                Date received : 15 May 2022
                Date accepted : 08 October 2022
                Page count
                Figures: 5, Tables: 1, Pages: 6, Words: 2250
                Categories
                Subject: Case Report
                Subject: Case Report
                Custom metadata
                source-schema-version-number 2.0
                cover-date November 2022
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:6.2.1 mode:remove_FC converted:19.11.2022

                Keywords: immunotherapy,melanoma,rare localization
                Data availability:
                Keywords: immunotherapy, melanoma, rare localization

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