Clinical Outcomes Associated With Sickle Cell Trait

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Although sickle cell trait (SCT) is largely a benign carrier state, it may increase risk for certain clinical outcomes.

Related collections

Most cited references 45

Record: found
Abstract: found
Article: not found

AHRQ series paper 5: grading the strength of a body of evidence when comparing medical interventions--agency for healthcare research and quality and the effective health-care program.

Douglas Owens, Kathleen N. Lohr, David Atkins … (2010)

To establish guidance on grading strength of evidence for the Evidence-based Practice Center (EPC) program of the U.S. Agency for Healthcare Research and Quality. Authors reviewed authoritative systems for grading strength of evidence, identified domains and methods that should be considered when grading bodies of evidence in systematic reviews, considered public comments on an earlier draft, and discussed the approach with representatives of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group. The EPC approach is conceptually similar to the GRADE system of evidence rating; it requires assessment of four domains: risk of bias, consistency, directness, and precision. Additional domains to be used when appropriate include dose-response association, presence of confounders that would diminish an observed effect, strength of association, and publication bias. Strength of evidence receives a single grade: high, moderate, low, or insufficient. We give definitions, examples, mechanisms for scoring domains, and an approach for assigning strength of evidence. EPCs should grade strength of evidence separately for each major outcome and, for comparative effectiveness reviews, all major comparisons. We will collaborate with the GRADE group to address ongoing challenges in assessing the strength of evidence.

0 comments Cited 103 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Complications associated with sickle cell trait: a brief narrative review.

Geoffrey Tsaras, Amma T Owusu-Ansah, Freda Boateng … (2009)

Sickle cell trait occurs in approximately 300 million people worldwide, with the highest prevalence of approximately 30% to 40% in sub-Saharan Africa. Long considered a benign carrier state with relative protection against severe malaria, sickle cell trait occasionally can be associated with significant morbidity and mortality. Sickle cell trait is exclusively associated with rare but often fatal renal medullary cancer. Current cumulative evidence is convincing for associations with hematuria, renal papillary necrosis, hyposthenuria, splenic infarction, exertional rhabdomyolysis, and exercise-related sudden death. Sickle cell trait is probably associated with complicated hyphema, venous thromboembolic events, fetal loss, neonatal deaths, and preeclampsia, and possibly associated with acute chest syndrome, asymptomatic bacteriuria, and anemia in pregnancy. There is insufficient evidence to suggest an independent association with retinopathy, cholelithiasis, priapism, leg ulcers, liver necrosis, avascular necrosis of the femoral head, and stroke. Despite these associations, the average life span of individuals with sickle cell trait is similar to that of the general population. Nonetheless, given the large number of people with sickle cell trait, it is important that physicians be aware of these associations.

0 comments Cited 96 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Development of the RTI item bank on risk of bias and precision of observational studies.

Meera Cozhimuttam Viswanathan, Nancy D Berkman (2012)

To create a practical and validated item bank for evaluating the risk of bias and precision of observational studies of interventions or exposures included in systematic evidence reviews. The item bank, developed at RTI International, was created based on 1,492 questions included in earlier instruments, organized by the quality domains identified by Deeks et al. Items were eliminated and refined through face validity, cognitive, content validity, and interrater reliability testing. The resulting item bank consisting of 29 questions for evaluating the risk of bias and precision of observational studies of interventions or exposures (1) captures all of the domains critical for evaluating this type of research, (2) is comprehensive and can be easily lifted "off the shelf" by different researchers, (3) can be adapted to different topic areas and study types (e.g., cohort, case-control, cross-sectional, and case series studies), and (4) provides sufficient instruction to apply the tool to varied topics. One bank of items, with specific instructions for focusing abstractor evaluations, can be created to judge the risk of bias and precision of the variety of observational studies that may be used in systematic and comparative effectiveness reviews. Copyright © 2012 Elsevier Inc. All rights reserved.

0 comments Cited 91 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Title: Annals of Internal Medicine

Abbreviated Title: Ann Intern Med

Publisher: American College of Physicians

ISSN (Print): 0003-4819

Publication date Created: November 06 2018

Publication date (Electronic): October 30 2018

Publication date (Print): November 06 2018

Volume: 169

Issue: 9

Page: 619

Affiliations

[1 ]Johns Hopkins University, Baltimore, Maryland (R.P.N.)

[2 ]Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania (K.S., P.S.)

[3 ]University of Colorado Denver School of Medicine, Denver, Colorado (K.L.H.)

[4 ]National Human Genome Research Institute of the National Institutes of Health, Bethesda, Maryland (N.I.U., J.J., V.L.B.)

[5 ]Hôpital Universitaire Necker–Enfants Malades, Paris, France (M.D.)

[6 ]Johns Hopkins Berman Institute of Bioethics, Baltimore, Maryland (C.H.)

[7 ]American College of Medical Genetics and Genomics, Bethesda, Maryland (M.A.L.)

[8 ]University of Pennsylvania, Philadelphia, Pennsylvania; Johns Hopkins Berman Institute of Bioethics, Baltimore, Maryland; Emory University School of Medicine, Atlanta, Georgia (C.H.J.)

[9 ]Vascular Medicine Institute at the University of Pittsburgh, Pittsburgh, Pennsylvania (G.J.K.)

Article

DOI: 10.7326/M18-1161

PMC ID: 6487193

PubMed ID: 30383109

SO-VID: 0d0549ee-f595-47e6-ba4a-fd5e57f25b32

History

Data availability:

Comments

Comment on this article

scite_

Cited by 30

See all cited by

Most referenced authors 599

See all reference authors

- Version 1
- Version 1

Clinical Outcomes Associated With Sickle Cell Trait : A Systematic Review

Read this article at

Abstract

Related collections

ScienceOpen Clinical Case Reports Collection

Most cited references 45

AHRQ series paper 5: grading the strength of a body of evidence when comparing medical interventions--agency for healthcare research and quality and the effective health-care program.

Complications associated with sickle cell trait: a brief narrative review.

Development of the RTI item bank on risk of bias and precision of observational studies.

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Similar content 2,863

Cited by 30

Most referenced authors 599