A General Small-Scale Reactor To Enable Standardization and Acceleration of Photocatalytic Reactions

Abstract

Photocatalysis for organic synthesis has experienced an exponential growth in the past 10 years. However, the variety of experimental procedures that have been reported to perform photon-based catalyst excitation has hampered the establishment of general protocols to convert visible light into chemical energy. To address this issue, we have designed an integrated photoreactor for enhanced photon capture and catalyst excitation. Moreover, the evaluation of this new reactor in eight photocatalytic transformations that are widely employed in medicinal chemistry settings has confirmed significant performance advantages of this optimized design while enabling a standardized protocol.

Abstract

An integrated photoreactor allows for enhanced photon capture and enables a standardized protocol for photocatalytic methodologies. The evaluation of this reactor in eight transformations showed significant rate enhancement and good reproducibility.