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<h5 class="section-title" id="d4249720e325">Study Objectives:</h5>
<p id="d4249720e327">To assess whether poor sleep quality experienced by regular shift
workers and individuals
with obstructive sleep apnea (OSA) affects neurobehavioral function similarly, or
whether the different etiologies have distinct patterns of impairment.
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<h5 class="section-title" id="d4249720e330">Methods:</h5>
<p id="d4249720e332">Thirty-seven shift workers (> 24 hours after their last shift),
36 untreated patients
with OSA, and 39 healthy controls underwent assessment of sleepiness (Epworth Sleepiness
Scale [ESS]), mood (Beck Depression Index, State Trait Anxiety Inventory [STAI], Profile
of Mood States), vigilance (Psychomotor Vigilance Task [PVT], Oxford Sleep Resistance
Test [OSLER], driving simulation), neurocognitive function (Logical Memory, Trails
Making Task, Digit Span Task, Victoria Stroop Test) and polysomnography.
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<h5 class="section-title" id="d4249720e335">Results:</h5>
<p id="d4249720e337">Sleepiness (ESS score; median, interquartile range) did not differ
between the OSA
(10.5, 6.3–14) and shift work (7, 5–11.5) groups, but both had significantly elevated
scores relative to the control group (5, 3–6). State anxiety (STAI-S) was the only
mood variable that differed significantly between the OSA (35, 29–43) and shift work
(30, 24–33.5) groups, however both demonstrated several mood deficits relative to
the control group. The shift work and control groups performed similarly on neurobehavioral
tasks (simulated driving, PVT, OSLER and neurocognitive tests), whereas the OSA group
performed worse. On the PVT, lapses were significantly greater for the OSA group (3,
2–6) than both the shift work (2, 0–3.5) and control (1, 0–4) groups.
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<h5 class="section-title" id="d4249720e340">Conclusions:</h5>
<p id="d4249720e342">Shift workers and patients with OSA had similar sleepiness and
mood deficits relative
to healthy individuals. However, only the patients with OSA showed deficits on vigilance
and neurocognitive function relative to healthy individuals. These findings suggest
that distinct causes of sleep disturbance likely result in different patterns of neurobehavioral
dysfunction.
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<h5 class="section-title" id="d4249720e345">Citation:</h5>
<p id="d4249720e347">Cori JM, Jackson ML, Barnes M, Westlake J, Emerson P, Lee J,
Galante R, Hayley A,
Wilsmore N, Kennedy GA, Howard M. The differential effects of regular shift work and
obstructive sleep apnea on sleepiness, mood and neurocognitive function.
<i>J Clin Sleep Med.</i> 2018;14(6):941–951.
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