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      Can patient-reported outcomes and inflammatory markers define endotype 2 in chronic rhinosinusitis without nasal polyps?

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          Abstract

          Chronic rhinosinusitis (CRS) is a heterogeneous disease at the clinical phenotype level (without nasal polyp [CRSsNP] vs with nasal polyp [CRSwNP]) and at the underlying inflammatory endotype level (type 2 vs non-type 2). Whether the endotype is associated with clinical presentation in patients with CRSsNP has yet to be explored in detail.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Ann Allergy Asthma Immunol
          Title: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
          Publisher: Elsevier BV
          ISSN (Electronic): 1534-4436
          ISSN (Print): 1081-1206
          Publication date (Electronic): Apr 2023
          Volume: 130
          Issue: 4
          Affiliations
          [1 ] Upper Airways Research Laboratory, Faculty of Medicine, Ghent University, Ghent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Heidelberg, Germany. Electronic address: Michaela.Plath@med.uni-heidelberg.de.
          [2 ] Upper Airways Research Laboratory, Faculty of Medicine, Ghent University, Ghent, Belgium.
          [3 ] GESIS-Leibniz-Institute for the Social Sciences, Mannheim, Germany.
          [4 ] Upper Airways Research Laboratory, Faculty of Medicine, Ghent University, Ghent, Belgium; Department of Sense Organs, Sapienza University of Rome, Rome, Italy.
          [5 ] Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Heidelberg, Germany.
          [6 ] Upper Airways Research Laboratory, Faculty of Medicine, Ghent University, Ghent, Belgium; Otolaryngology Department, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China; Division of ENT Diseases, CLINTEC, Karolinska Institute, Stockholm, Sweden.
          Article
          Publisher Item ID: S1081-1206(22)01961-5
          DOI: 10.1016/j.anai.2022.11.020
          PubMed ID: 36442791
          SO-VID: 0e2aeb5c-16a1-4f30-b5d6-e4970953ea73
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