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      Anchorage Dependence of Lens Epithelial Cells. DNA and Protein Synthesis in Untransformed and Transformed Cells

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          Abstract

          Substrata which facilitate (glass) or prevent (agarose gel) cell attachment were used for studying anchorage dependence of two cell lines derived from bovine eye lenses. DNA and protein synthesis were measured in attached and floating lens cells and compared with that of transformed mouse fibroblasts (L cells). Untransformed lens epithelial cells proved to be strongly anchorage dependent, but anchorage dependence was reduced in an established line of spontaneously transformed lens epithelial cells and largely lost in transformed mouse fibroblasts.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1980
          1980
          03 December 2009
          : 12
          : 1
          : 34-37
          Affiliations
          Institute of Physiological Chemistry, Martin Luther University, Halle/Saale
          Article
          265058 Ophthalmic Res 1980;12:34–37
          10.1159/000265058
          0e523966-696a-4a08-acd7-11b745be91ed
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 23 April 1979
          : 11 September 1979
          Page count
          Pages: 4
          Categories
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Anchorage dependence,Cell-substratum interaction,Growth regulation,Transformed lens cells,Lens epithelial cells,DNA synthesis,Protein synthesis

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