There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
The aim of this study was to perform the frequency distribution of MDR1 gene SNPs
and haplotypes of Jiangsu Han population in China. A total of 225 Jiangsu Han unrelated
volunteers were enrolled and genotyped by PCR-ASP method at three loci: C1236T (rs1128503),
G2677T/A (rs2032582) and C3435T (rs1045642). In total, C and T were found at locus
1236, with the frequency of 35% and 65%, respectively. The most frequent allele at
locus 2677 was G with the frequency of 44%, followed by T (41%) and A (15%). At locus
3435, C was more common (60%) than T (40%). The most common haplotype at loci 1236-2677-3435
was T-T-T (31.84%), at loci 1236-2677 was T-T (37.68%), at loci 2677-3435 was G-C
(39.06%), and at loci 1236-3435 was T-T (34.28%). The haplotype linkage disequilibrium
study found that all three loci were in linkage disequilibrium, such as T-T at loci
1236-2677, T-T at loci 2677-3435 and C-C at loci 1236-3435 (P<0.01). The dendrogram
study indicated that the distribution of MDR1 SNPs in Jiangsu Han population were
close to Japan and Malay populations and far away from European countries. These findings
could shade new lights in population genetics and anthropology studies of Han-Chinese.
It also provides basic data for research on MDR1 gene polymorphism, disease association
and drug resistance study.