Catechol-O-methyltransferase association with hemoglobin A1c.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Catecholamines have metabolic effects on blood pressure, insulin sensitivity and blood glucose. Genetic variation in catechol-O-methyltransferase (COMT), an enzyme that degrades catecholamines, is associated with cardiometabolic risk factors and incident cardiovascular disease (CVD). Here we examined COMT effects on glycemic function and type 2 diabetes.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Metab. Clin. Exp.

Title: Metabolism: clinical and experimental

Publisher: Elsevier BV

ISSN (Electronic): 1532-8600

ISSN (Print): 0026-0495

Publication date (Electronic): Jul 2016

Volume: 65

Issue: 7

Affiliations

[1 ] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: khall0@partners.org.

[2 ] The Biostatistics Center, George Washington University, Rockville, MD, USA.

[3 ] Center for Human Genetic Research and Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.

[4 ] Genomics Platform, Broad Institute, Cambridge, MA, USA.

[5 ] Division of General Medicine and Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

[6 ] Harvard Medical School, Boston, MA, USA; Division of General Medicine and Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

[7 ] Pennington Biomedical Research Center, Baton Rouge, LA 70808.

[8 ] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

[9 ] Harvard Medical School, Boston, MA, USA; Center for Human Genetic Research and Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.

Article

Publisher Item ID: S0026-0495(16)30004-X Mid ID: NIHMS793278

DOI: 10.1016/j.metabol.2016.04.001

PMC ID: 4924514

PubMed ID: 27282867

SO-VID: 10ac3ff2-83a9-4180-8455-c026686f5acb

History

Keywords: COMT,Diabetes Prevention Program (DPP),Hemoglobin A1C,Type 2 diabetes,Women's Health Study (WHS)

Data availability:

Keywords: COMT, Diabetes Prevention Program (DPP), Hemoglobin A1C, Type 2 diabetes, Women's Health Study (WHS)

Catechol-O-methyltransferase association with hemoglobin A1c.

Read this article at

Abstract

Related collections

Association of European University Presses (AEUP)

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Similar content 253

Cited by 7