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      Bombesin-Like Immunoreactivity in the Forebrain and Pituitary and Regulation of Anterior Pituitary Hormone Release by Bombesin in Goldfish

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          Abstract

          The presence and distribution of bombesin (BBS)/gastrin-releasing peptide (GRP)-like immunoreactivity (IR) was examined in the goldfish pituitary and forebrain. BBS/GRP-like IR nerve fibres were consistently observed throughout the pituitary neurointermediate lobe (); occasionally, BBS/GRP-like material was localized in cells and few fibres within the pars distalis. Within the goldfish forebrain, sparse, fine-beaded BBS/GRP-like IR fibres and few perikarya were detected in the preoptic hypothalamus. BBS/GRP-like IR material was also present in the ventro-posterior hypothalamus and the hypothalamic inferior lobes, and, in particular, within the nucleus lateral tuberis pars anterioris (NLTa) and nucleus lateral tuberis pars posterioris (NLTp), nucleus anterior tuberis (NAT), nucleus recessus lateralis (NRL), nucleus recessus posterioris (NRP), and the nucleus diffusus lobi inferioris (NDLI). Several BBS/GRP-like IR perikarya were observed in periventricular regions of the NLT, NRL, and NRP. Finally, BBS/GRP-like IR material was detected in the nucleus habenularis, the nucleus rotundus, several thalamic nuclei, and the optic tectum of the dorso-posterior diencephalon. The presence of BBS/ GRP-like IR material within the preoptic hypothalamus, hypophysial stalk, and in the pituitary suggests that BBS-like peptides may regulate pituitary hormone release in fish. Perifusion of goldfish pituitary fragments with initial pulses of 0.1,10,100 or 1,000 nMBBS stimulated both growth hormone (GH) and gonadotropin (GtH-II) release. Repeated pulses of the same dose of BBS generally stimulated GH and GtH-II release to a similar magnitude. These studies provide initial evidence that BBS/GRP-like peptides are present within the central nervous system of teleost fish. The anatomical distribution of BBS/ GRP-like IR in goldfish hypothalamic feeding center supports our previous report indicating a role for BBS in the central regulation of food intake in fish. Additionally, the presence of BBS/GRP-like IR material in the pituitary and brain areas associated with the regulation of anterior pituitary hormone secretion, as well as evidence demonstrating a direct action of BBS at the level of the goldfish pituitary to modify GH and GtH-II secretion, indicates that BBS/ GRP-like peptides likely act to regulate pituitary hormone release in teleosts.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1995
          1995
          09 April 2008
          : 61
          : 4
          : 365-376
          Affiliations
          Department of Biological Sciences, University of Alberta, Edmonton, Alta, Canada
          Article
          126858 Neuroendocrinology 1995;61:365–376
          10.1159/000126858
          7783850
          © 1995 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 12
          Categories
          Distribution and Effects of Neuropeptides or Neurotransmitters

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