For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
2
views
45
references
 Top references
cited by
2
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      94
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      The role of medication adherence in the association between depressive symptoms and quality of life in older adults with type 2 diabetes mellitus

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          At present, the role of medication adherence in the association between depressive symptoms and quality of life (QOL) in older adults with type 2 diabetes mellitus (T2DM) was unclear. The purpose of this study was to explore the associations among depressive symptoms, medication adherence and QOL in older adults with T2DM.

          Methods

          In this cross-sectional study, 300 older adults with T2DM from the First Affiliated Hospital of Anhui Medical University were enrolled. Among them, 115 patients had depressive symptoms and 185 had no depressive symptoms. Univariate linear regression analysis was conducted to identify possible covariates. Univariate and multivariable linear regression analyses were performed to explore the associations between depressive symptoms and medication adherence or QOL in older adults with T2DM. Multiplicative interaction analysis was evaluated whether there was interaction effect between medication adherence and depressive symptoms on QOL of patients. Mediating effect analysis was used to analyze the medication effect of medication adherence on depressive symptoms and QOL in older adults with T2DM.

          Results

          Decreased medication adherence was observed in patients with depressive symptoms (β = -0.67, 95%CI: -1.10, -0.24) after adjusting for covariates. Depressive symptoms were associated with decreased QOL in older adults with T2DM (β = -5.99, 95%CI: -7.56, -4.42). The mediating analysis revealed that depressive symptoms were associated with decreased medication adherence (β = -0.67, 95%CI: -1.09, -0.25). Medication adherence was linked with increased QOL of older adults with T2DM (β = 0.65, 95%CI: 0.24, 1.06). Depressive symptoms were correlated with decreased QOL of older adults with T2DM (β = -5.56, 95%CI: -7.10, -4.01). The percentage mediated by medication adherence on depressive symptoms and QOL in older adults with T2DM was 10.61%.

          Conclusion

          Medication adherence might mediate depressive symptoms and QOL of older adults with T2DM, which might provide a reference for the improvement of QOL of these patients.

          Supplementary Information

          The online version contains supplementary material available at 10.1186/s12877-023-03929-8.

          Related collections

          Most cited references45

          • Record: found
          • Abstract: found
          • Article: not found

          Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

          Sylvia Ley, Yan Zheng, Frank Hu (2017)
          Globally, the number of people with diabetes mellitus has quadrupled in the past three decades, and diabetes mellitus is the ninth major cause of death. About 1 in 11 adults worldwide now have diabetes mellitus, 90% of whom have type 2 diabetes mellitus (T2DM). Asia is a major area of the rapidly emerging T2DM global epidemic, with China and India the top two epicentres. Although genetic predisposition partly determines individual susceptibility to T2DM, an unhealthy diet and a sedentary lifestyle are important drivers of the current global epidemic; early developmental factors (such as intrauterine exposures) also have a role in susceptibility to T2DM later in life. Many cases of T2DM could be prevented with lifestyle changes, including maintaining a healthy body weight, consuming a healthy diet, staying physically active, not smoking and drinking alcohol in moderation. Most patients with T2DM have at least one complication, and cardiovascular complications are the leading cause of morbidity and mortality in these patients. This Review provides an updated view of the global epidemiology of T2DM, as well as dietary, lifestyle and other risk factors for T2DM and its complications.
          Article 0 comments Cited 1358 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Predictive validity of a medication adherence measure in an outpatient setting.

            Donald E. Morisky, Alfonso Ang, Marie Krousel-Wood … (2008)
            This study examines the psychometric properties and tests the concurrent and predictive validity of a structured, self-reported medication adherence measure in patients with hypertension. The authors also assessed various psychosocial determinants of adherence, such as knowledge, social support, satisfaction with care, and complexity of the medical regimen. A total of 1367 patients participated in the study; mean age was 52.5 years, 40.8% were male, 76.5% were black, 50.8% graduated from high school, 26% were married, and 54.1% had income <$5,000. The 8-item medication adherence scale was reliable (alpha=.83) and significantly associated with blood pressure control (P<.05). Using a cutpoint of <6, the sensitivity of the measure to identify patients with poor blood pressure control was estimated to be 93%, and the specificity was 53%. The medication adherence measure proved to be reliable, with good concurrent and predictive validity in primarily low-income, minority patients with hypertension and might function as a screening tool in outpatient settings with other patient groups.
            Article 0 comments Cited 347 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found
              Is Open Access

              How Reliable are Measurement Scales? External Factors with Indirect Influence on Reliability Estimators

              George Ursachi, Ioana Alexandra Horodnic, Adriana Zait (2015)
              Article 0 comments Cited 197 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Hao Yang: yhahmu@163.com
                Journal
                Journal ID (nlm-ta): BMC Geriatr
                Journal ID (iso-abbrev): BMC Geriatr
                Title: BMC Geriatrics
                Publisher: BioMed Central (London )
                ISSN (Electronic): 1471-2318
                Publication date (Electronic): 30 March 2023
                Publication date PMC-release: 30 March 2023
                Publication date Collection: 2023
                Volume: 23
                Electronic Location Identifier: 196
                Affiliations
                GRID grid.412679.f, ISNI 0000 0004 1771 3402, Department of Geriatric Endocrinology, , The First Affiliated Hospital of Anhui Medical University, ; No.218 of Jixi Road, Shushan District, Hefei, 230032 Anhui China
                Article
                Publisher ID: 3929
                DOI: 10.1186/s12877-023-03929-8
                PMC ID: 10064516
                PubMed ID: 36997851
                SO-VID: 112ddbe6-1d0e-44d0-829c-2d1657b4f6c4
                Copyright © © The Author(s) 2023
                License:

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                Date received : 28 September 2022
                Date accepted : 24 March 2023
                Funding
                Funded by: Scientific Research Foundation of Anhui Medical Universit
                Award ID: 2020xkj164
                Award ID: 2020xkj164
                Award ID: 2020xkj164
                Award ID: 2020xkj164
                Award ID: 2020xkj164
                Award Recipient :
                Funded by: the Natural Science Foundation of Anhui Education Department
                Award ID: KJ2021A0277
                Award ID: KJ2021A0277
                Award ID: KJ2021A0277
                Award ID: KJ2021A0277
                Award ID: KJ2021A0277
                Award Recipient :
                Categories
                Subject: Research
                Custom metadata
                issue-copyright-statement © The Author(s) 2023

                ScienceOpen disciplines: Geriatric medicine
                Keywords: type 2 diabetes mellitus,quality of life,depressive symptoms,medication adherence
                Data availability:
                ScienceOpen disciplines: Geriatric medicine
                Keywords: type 2 diabetes mellitus, quality of life, depressive symptoms, medication adherence

                Comments

                Comment on this article

                scite_

                Similar content94

                See all similar

                Cited by2

                See all cited by

                Most referenced authors680

                See all reference authors