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      Use of Historical Control Data in Carcinogenicity Studies in Rodents

      Author(s): , ,
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      Journal: Toxicologic Pathology
      Publisher: SAGE Publications

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          Neoplastic and nonneoplastic lesions in aging F344 rats.

          M Linhart, G. Squire, S. Ward … (1979)
          Article 0 comments Cited 51 times – based on 0 reviews     Review now
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            A Biometrics Invited Paper with Discussion. Some Aspects of Analysis of Covariance

            D R Cox, P. McCullagh (1982)
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              Neoplastic and nonneoplastic lesions in aging (C57BL/6N x C3H/HeN)F1 (B6C3F1) mice.

              M Linhart, G. Squire, Christopher D Goodman … (1979)
              Neoplastic and nonneoplastic lesions in untreated (C57BL/6N x C3H/HeN)F1 (B6C3F1) mice used as controls in carcinogenesis tests were tabulated and evaluated. The most common neoplasms in 2,543 male mice were hepatocellular adenomas and carcinomas. In 2,522 female mice, common tumors were lymphomas, leukemias, pulmonary adenomas and carcinomas, hepatocellular adenomas and carcinomas, and pituitary adenomas. The risk of developing most neoplasms increased with the age of the mouse. Hepatocellular carcinomas metastasized in 12% of the animals with these tumors. Other than lymphomas and leukemias, few other tumors metastasized. Nonneoplastic lesions included cystic hyperplasia of the uterus, nephritis, ovarian and uterine cysts, inflammatory lesions of the lung, mineralization in the brain, and focal hyperplasias in several tissues. The focal hyperplasias in lung and pituitary, adrenal, and thyroid glands were suggestive of the early stages of neoplasia. Comparative aspects of lesions in aging mice and their interpretation in carcinogenesis tests are discussed.
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                Author and article information

                Journal
                Title: Toxicologic Pathology
                Abbreviated Title: Toxicol Pathol
                Publisher: SAGE Publications
                ISSN (Print): 0192-6233
                ISSN (Electronic): 1533-1601
                Publication date Created: June 25 2016
                Publication date (Print): June 25 2016
                Volume: 12
                Issue: 2
                Pages: 126-135
                Article
                DOI: 10.1177/019262338401200203
                SO-VID: 117f0530-d3a0-4703-95a0-c08786aba65e
                Copyright © © 2016
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