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      Leishmaniasis cutánea en Colombia: una mirada epidemiológica

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          Abstract

          Resumen La leishmaniasis resulta una enfermedad infectocontagiosa causada por un protozoo del género Leishmania. Esta constituye un problema de salud importante para diversas regiones de América Latina. El aislamiento social impuesta a raíz de la pandemia de COVID-19 favoreció que disminuyera la incidencia de esta entidad, pero las actividades sociales de la normalidad se retomaron paulatinamente, imponiéndose que se retomen las medidas de seguimiento y control correspondientes.

          Translated abstract

          Abstract Leishmaniasis is an infectious disease caused by a protozoan of the genus Leishmania. Leishmaniasis constitutes a significant health problem for various regions of Latin America. The social isolation imposed because of the COVID-19 pandemic favored a decrease in the incidence of this entity. However, regular social activities were gradually resumed, imposing the corresponding monitoring and control measures.

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          Cutaneous and Mucocutaneous Leishmaniasis.

          I Abadías-Granado, A Diago, P A Cerro … (2021)
          Leishmaniasis is a chronic disease caused by flagellate protozoa of the genus Leishmania. It is a global disease, but most cases are seen in South America, the Mediterranean, and some areas of Asia and Africa. The 3 main types of leishmaniasis are cutaneous (the most common), mucocutaneous, and visceral (the most severe). Visceral leishmaniasis is also known as kala-azar. Leishmaniasis is diagnosed by demonstrating the presence of Leishmania amastigotes in clinical specimens using direct microscopic examination or molecular analysis. Various treatments exist, although the evidence supporting the options available for cutaneous leishmaniasis is weak. Both the classical presentation of leishmaniasis and our management of the disease have changed in recent decades because of acquired immune deficiency caused by conditions such as human immunodeficiency infection or the use of tumor necrosis factor inhibitors.
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            Colombian Contributions Fighting Leishmaniasis: A Systematic Review on Antileishmanials Combined with Chemoinformatics Analysis

            Jeysson Sánchez-Suárez, Freddy A. Bernal, Ericsson D. Coy-Barrera (2020)
            Leishmaniasis is a parasitic morbid/fatal disease caused by Leishmania protozoa. Twelve million people worldwide are appraised to be currently infected, including ca. two million infections each year, and 350 million people in 88 countries are at risk of becoming infected. In Colombia, cutaneous leishmaniasis (CL) is a public health problem in some tropical areas. Therapeutics is based on traditional antileishmanial drugs, but this practice has several drawbacks for patients. Thus, the search for new antileishmanial agents is a serious need, but the lack of adequately funded research programs on drug discovery has hampered its progress. Some Colombian researchers have conducted different research projects focused on the assessment of the antileishmanial activity of naturally occurring and synthetic compounds against promastigotes and/or amastigotes. Results of such studies have separately demonstrated important hits and reasonable potential, but a holistic view of them is lacking. Hence, we present the outcome from a systematic review of the literature (under PRISMA guidelines) on those Colombian studies investigating antileishmanials during the last thirty-two years. In order to combine the general efforts aiming at finding a lead against Leishmania panamensis (one of the most studied and incident parasites in Colombia causing CL) and to recognize structural features of representative compounds, fingerprint-based analyses using conventional machine learning algorithms and clustering methods are shown. Abstraction from such a meta-description led to describe some function-determining molecular features and simplify the clustering of plausible isofunctional hits. This systematic review indicated that the Colombian efforts for the antileishmanials discovery are increasingly intensified, though improvements in the followed pathways must be definitively pursued. In this context, a brief discussion about scope, strengths and limitations of such advances and relationships is addressed.
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              Carga parasitaria de Leishmania spp. en personal militar colombiano con leishmaniasis cutánea.

              CP Méndez-Bejarano, CA Correa-Cardenas, JJ Pérez-Rico … (2020)
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                Author and article information

                Journal
                Journal ID (publisher-id): ree
                Title: Revista Eugenio Espejo
                Abbreviated Title: Rev Eug Esp
                Publisher: Universidad Nacional de Chimborazo (Riobamba, Chimborazo, Ecuador )
                ISSN (Print): 1390-7581
                ISSN (Electronic): 2661-6742
                Publication date (Print and electronic): April 2023
                Volume: 17
                Issue: 1
                Pages: 5-7
                Affiliations
                [2] orgnameGrupo interdisciplinario de investigación en epidemiología y salud pública, Colombia
                [1] orgnameHospital Universitario del Valle Colombia
                [3] orgnameHospital Universitario del Valle Colombia
                Article
                Publisher ID: S2661-67422023000100005 Publisher ID: S2661-6742(23)01700100005
                DOI: 10.37135/ee.04.16.02
                SO-VID: 11d64431-3c39-4b78-966c-cbf92c13ed35
                License:

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

                History
                Date received : 23 August 2022
                Date accepted : 13 October 2022
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 4, Pages: 3
                Product

                SciELO null


                Keywords: leishmaniasis cutánea,Public Reporting of Healthcare Data,Skin Diseases,Leishmaniasis Cutaneous,reportes públicos de datos en atención de salud,enfermedades de la piel
                Data availability:
                Keywords: leishmaniasis cutánea, Public Reporting of Healthcare Data, Skin Diseases, Leishmaniasis Cutaneous, reportes públicos de datos en atención de salud, enfermedades de la piel

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