Efficiently Maintaining a National Resource of Historical and Contemporary Biological Collections: The NHLBI Biorepository Model

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Abstract

Introduction: Reducing costs by improving storage efficiency has been a focus of the National Heart, Lung, and Blood Institute (NHLBI) Biologic Specimen Repository (Biorepository) and Biologic Specimen and Data Repositories Information Coordinating Center (BioLINCC) programs for several years.

Methods: Study specimen profiles were compiled using the BioLINCC collection catalog. Cost assessments and calculations on the return on investments to consolidate or reduce a collection, were developed and implemented.

Results: Over the course of 8 months, the NHLBI Biorepository evaluated 35 collections that consisted of 1.8 million biospecimens. A total of 23 collections were selected for consolidation, with a total of 1.2 million specimens located in 21,355 storage boxes. The consolidation resulted in a savings of 4055 boxes of various sizes and 10.2 mechanical freezers (∼275 cubic feet) worth of space.

Conclusion: As storage costs in a biorepository increase over time, the development and use of information technology tools to assess the potential advantage and feasiblity of vial consolidation can reduce maintenance expenses.

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Providing Contemporary Access to Historical Biospecimen Collections: Development of the NHLBI Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC)

Carol Giffen, Leslie Carroll, John Adams … (2015)

The National Heart, Lung, and Blood Institute (NHLBI), within the United States' National Institutes of Health (NIH), established a Biorepository in 1976 that initially archived biospecimens from population-based blood product safety surveys. It was later expanded to biospecimens from clinical and epidemiological studies in heart, lung, and blood disorders. The NHLBI also established a Data Repository in 2000 to store and distribute study data from NHLBI-sponsored research. The NHLBI Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC) was established in 2008 to develop the infrastructure needed to link the contents of these two related NHLBI Repositories, facilitate access to repository resources, and streamline request processes. Three key program subcomponents were developed simultaneously: 1) the linkage of biospecimen electronic inventory records with their clinical or characterization data; 2) the development and implementation of a website with both public-facing information and private processing workspaces; and 3) the development of processes to maximize efficiency via a web-based system while maintaining workflow control, document tracking, and secure processes. The BioLINCC website was launched on October 1, 2009 with eight biospecimen collections and data from 72 research studies. By the end of the fourth online year, 38 biospecimen collections were linked and posted, and data from 108 research studies had been made available for request. The number of registered users by the end of the fourth online year approached 2600, and continues to show a trend towards an increasing rate of new users per year. BioLINCC has fulfilled 381 requests comprising 851 data collections, as well as 600 teaching dataset requests and 75 data renewal agreements. 154 biospecimen requests comprising 147,388 biospecimens were fulfilled or actively in process. We conclude that the BioLINCC program has been successful in its goal to increase the visibility and utilization of NHLBI biospecimen and data repository resources.

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Non-A, non-B hepatitis and antibody to hepatitis C virus.

J W Mosley, R Aach, F Hollinger … (1990)

Stored serum samples from the Transfusion-transmitted Viruses Study in the 1970s were tested for the presence of antibody to hepatitis C virus (anti-HCV). Single specimens from five control subjects who did not receive transfusions tested negative for anti-HCV. Of four control subjects who did not receive transfusions and who developed non-A, non-B (NANB) hepatitis after hospitalization, three remained anti-HCV negative; the fourth person with postoperative NANB hepatitis tested anti-HCV positive before the operation. Five transfusion recipients with posttransfusion hepatitis B virus infection remained seronegative; a sixth with NANB hepatitis as well as hepatitis B virus infection had seroconversion for anti-HCV. Five of nine transfusion recipients with NANB hepatitis had anti-HCV seroconversion. These results show that present anti-HCV testing demonstrates an etiologic basis for approximately half of the cases of transfusion-associated NANB hepatitis, particularly those that develop chronicity. Although cases of NANB hepatitis without seroconversion may be explained otherwise, they may be caused by another, presently unidentified, virus.

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Building an online catalog to standardize and centralize the knowledge base of a diverse group of unique historical biospecimen collections: The NHLBI BioLINCC program approach

J Adams, C. Giffen, J Krzystan … (2015)

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Journal

Journal ID (nlm-ta): Biopreserv Biobank

Journal ID (iso-abbrev): Biopreserv Biobank

Journal ID (publisher-id): bio

Title: Biopreservation and Biobanking

Publisher: Mary Ann Liebert, Inc. (140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA )

ISSN (Print): 1947-5535

ISSN (Electronic): 1947-5543

Publication date (Print): 01 February 2017

Publication date (Electronic): 01 February 2017

Publication date PMC-release: 01 February 2017

Volume: 15

Issue: 1

Pages: 17-19

Affiliations

[ ¹ ]Precision For Medicine, Frederick, Maryland.

[ ² ]National Heart, Lung, and Blood Institute, Division of Blood Diseases and Resources, Bethesda, Maryland.

[ ³ ]Information Management Services, Inc. , Calverton, Maryland.

Author notes

[*]

Present affiliation: Brooks Biostorage Technologies, Brooks Life Science Systems, Indianapolis, IN.

Address correspondence to: Katheryn E. Shea, BS, Brooks Biostorage Technologies, Brooks Life Science Systems, 2910 Fortune Circle West, Indianapolis, IN 46241, E-mail: kathi.shea@ 123456brooks.com

Article

Publisher ID: 10.1089/bio.2016.0112

DOI: 10.1089/bio.2016.0112

PMC ID: 5326980

PubMed ID: 28186851

SO-VID: 12889cb1-7c6d-46f2-89eb-1b97ac3e60bf

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This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License ( http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

Efficiently Maintaining a National Resource of Historical and Contemporary Biological Collections: The NHLBI Biorepository Model

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Hogrefe: Sustainability & Psychology

Most cited references 7

Providing Contemporary Access to Historical Biospecimen Collections: Development of the NHLBI Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC)

Non-A, non-B hepatitis and antibody to hepatitis C virus.

Building an online catalog to standardize and centralize the knowledge base of a diverse group of unique historical biospecimen collections: The NHLBI BioLINCC program approach

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