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CYP3A activity in severe liver cirrhosis correlates with Child-Pugh and model for end-stage liver disease (MELD) scores.
Albader Albarmawi
1 ,
David Czock ,
Annika Gauss ,
Robert Ehehalt ,
Justo Lorenzo Bermejo ,
Jürgen Burhenne ,
Tom M Ganten ,
Peter Sauer ,
Walter E Haefeli
Jan 2014
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Abstract
Impaired liver function often necessitates drug dose adjustment to avoid excessive drug accumulation and adverse events, but a marker for the extent of the required adjustment is lacking. The aim of this study was to investigate whether Child-Pugh (CP) and model for end-stage liver disease (MELD) scores correlate with drug clearance.