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Parthenolide inhibits the initiation of experimental autoimmune neuritis.
Min Zhang
1 ,
Ru-Tao Liu
1 ,
Peng Zhang
1 ,
Na Zhang
1 ,
Chun-Lin Yang
1 ,
Long-Tao Yue
2 ,
Xiao-Li Li
1 ,
Yin Liu
1 ,
Heng Li
1 ,
Juan Du
2 ,
Rui-Sheng Duan
3
Apr 15 2017
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Abstract
A growing body of evidence suggests the anti-inflammatory and antitumor effects of parthenolide (PAR). Here we show that PAR treatment inhibits the initiation of experimental autoimmune neuritis (EAN), suppresses the production of TNF-α, IFN-γ, IL-1β and IL-17, and decreases Th1 and Th17 cells at early time point. However, such anti-inflammatory effect vanishes later and PAR impedes the recovery of EAN in late phase, which is accompanied with inhibited apoptosis of inflammatory cells. Our results indicate that PAR plays dual roles in EAN and it is not proper to be applied in autoimmune diseases of nervous system.