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      Multisystem Inflammatory Syndrome in Children (MIS-C) During SARS-CoV-2 Delta and Omicron Variant Circulation— United States, July 2021 – January 2022

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          Abstract

          We describe 2,116 multisystem inflammatory syndrome in children (MIS-C) cases reported to CDC during Delta and Omicron circulation from July 2021–January 2022. Half of MIS-C patients were aged 5-11 years, 52% received ICU-level care, and 1.1% died. Only 3.0% of eligible patients were fully vaccinated prior to MIS-C onset.

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          Author and article information

          Contributors
          Allison D. Miller
          Anna R. Yousaf
          Ethan Bornstein
          Michael J. Wu
          Katherine Lindsey
          Michael Melgar
          Matthew E. Oster
          Laura D. Zambrano
          Angela P. Campbell
          Journal
          Journal ID (nlm-ta): Clin Infect Dis
          Journal ID (iso-abbrev): Clin Infect Dis
          Journal ID (publisher-id): cid
          Title: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
          Publisher: Oxford University Press
          ISSN (Print): 1058-4838
          ISSN (Electronic): 1537-6591
          Publication date (Electronic): 10 June 2022
          Publication date PMC-release: 10 June 2022
          Electronic Location Identifier: ciac471
          Affiliations
          CDC COVID-19 Response Team, Centers for Disease Control and Prevention , Atlanta, GA, USA
          CDC COVID-19 Response Team, Centers for Disease Control and Prevention , Atlanta, GA, USA
          CDC COVID-19 Response Team, Centers for Disease Control and Prevention , Atlanta, GA, USA
          Epidemic Intelligence Service, Centers for Disease Control and Prevention , Atlanta, GA, USA
          Northwest Portland Area Indian Health Board , Portland, OR, USA
          CDC COVID-19 Response Team, Centers for Disease Control and Prevention , Atlanta, GA, USA
          CDC COVID-19 Response Team, Centers for Disease Control and Prevention , Atlanta, GA, USA
          CDC COVID-19 Response Team, Centers for Disease Control and Prevention , Atlanta, GA, USA
          CDC COVID-19 Response Team, Centers for Disease Control and Prevention , Atlanta, GA, USA
          Children’s Healthcare of Atlanta, Emory University School of Medicine , Atlanta, GA
          CDC COVID-19 Response Team, Centers for Disease Control and Prevention , Atlanta, GA, USA
          CDC COVID-19 Response Team, Centers for Disease Control and Prevention , Atlanta, GA, USA
          Author notes
          Corresponding author: Allison Miller Centers for Disease Control and Prevention 1600 Clifton Road NE Atlanta, GA 30329 United States amiller8@ 123456cdc.gov 404-718-6309
          Article
          Publisher ID: ciac471
          DOI: 10.1093/cid/ciac471
          PMC ID: 9214171
          PubMed ID: 35684958
          SO-VID: 18b3eadc-db15-4aa8-a344-c65ea1624821
          Copyright © © Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022.
          License:

          This work is written by (a) US Government employee(s) and is in the public domain in the US.

          This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

          History
          Date received : 03 April 2022
          Date revision received : 01 June 2022
          Date accepted : 03 June 2022
          Page count
          Pages: 12
          Categories
          Subject: Vaccines, Variants, and Vigilance Supplement
          Subject: AcademicSubjects/MED00290
          Custom metadata
          edited-state accepted-manuscript
          article-lifecycle PAP

          ScienceOpen disciplines: Infectious disease & Microbiology
          Keywords: multisystem inflammatory syndrome in children,covid-19,child,epidemiology
          Data availability:
          ScienceOpen disciplines: Infectious disease & Microbiology
          Keywords: multisystem inflammatory syndrome in children, covid-19, child, epidemiology

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