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      Anti-Inflammatory Effect of Glutathione Peroxidase on Experimental Lens-Induced Uveitis

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          Abstract

          An acute lens-induced necrotizing intraocular inflammation was produced in Lewis rats. Treatment of these animals by intraperitoneal injection of glutathione peroxidase resulted in marked decrease in uveal inflammation, retinal edema, hemorrhage and vasculitis. Intraperitoneal injection of glutathione peroxidase resulted in increased levels of this enzyme in ocular tissue. These findings suggest that glutathione peroxidase can modulate acute lens-induced ocular inflammation by serving as a potent anti-inflammatory agent.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1988
          1988
          10 December 2009
          : 20
          : 4
          : 213-219
          Affiliations
          aEstelle Doheny Eye Foundation; bDepartments of Ophthalmology and Pathology, Institute for Toxicology, University of Southern California, Los Angeles, Calif.; cDepartment of Pathology, University of Michigan, Ann Arbor, Mich.; dCenter for Sight, Washington, D.C., USA
          Article
          266645 Ophthalmic Res 1988;20:213–219
          10.1159/000266645
          3263601
          193313bf-0722-4122-acce-09793a061b0f
          © 1988 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 11 June 1987
          : 24 September 1987
          Page count
          Pages: 7
          Categories
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Antioxidants,Glutathione peroxidase,Catalase,Lipid peroxidation,Lens-induced uveitis

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