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      • Record: found
      • Abstract: found
      • Article: found

      Anti-Inflammatory Effect of Glutathione Peroxidase on Experimental Lens-Induced Uveitis

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          Abstract

          An acute lens-induced necrotizing intraocular inflammation was produced in Lewis rats. Treatment of these animals by intraperitoneal injection of glutathione peroxidase resulted in marked decrease in uveal inflammation, retinal edema, hemorrhage and vasculitis. Intraperitoneal injection of glutathione peroxidase resulted in increased levels of this enzyme in ocular tissue. These findings suggest that glutathione peroxidase can modulate acute lens-induced ocular inflammation by serving as a potent anti-inflammatory agent.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1988
          Publication date (Print): 1988
          Publication date (Electronic): 10 December 2009
          Volume: 20
          Issue: 4
          Pages: 213-219
          Affiliations
          aEstelle Doheny Eye Foundation; bDepartments of Ophthalmology and Pathology, Institute for Toxicology, University of Southern California, Los Angeles, Calif.; cDepartment of Pathology, University of Michigan, Ann Arbor, Mich.; dCenter for Sight, Washington, D.C., USA
          Article
          Publisher ID: 266645 Other ID: Ophthalmic Res 1988;20:213–219
          DOI: 10.1159/000266645
          PubMed ID: 3263601
          SO-VID: 193313bf-0722-4122-acce-09793a061b0f
          Copyright © © 1988 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 11 June 1987
          Date accepted : 24 September 1987
          Page count
          Pages: 7
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Antioxidants,Glutathione peroxidase,Catalase,Lipid peroxidation,Lens-induced uveitis
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Antioxidants, Glutathione peroxidase, Catalase, Lipid peroxidation, Lens-induced uveitis

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