Film dressings from Thai mango seed kernel extracts versus nanocrystalline silver dressings in antibacterial properties

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Abstract

Introduction: The extract from the Mango Seed Kernel (MSK) has been documented to exhibit antibacterial activity against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa. This suggests that biomaterials containing MSK extract could be a viable alternative to conventional wound treatments, such as nanocrystalline silver dressings. Despite this potential, there is a notable gap in the literature regarding comparing the antibacterial effectiveness of MSK film dressings with nanocrystalline silver dressings. This study aimed to develop film dressings containing MSK extract and evaluate their antibacterial properties compared to nanocrystalline silver dressings. Additionally, the study aimed to assess other vital physical properties of these dressings critical for effective wound care.

Materials and methods: We prepared MSK film dressings from two cultivars of mango from Thailand, ‘Chokanan’ and ‘Namdokmai’. The inhibition-zone method was employed to determine the antibacterial property. The morphology and chemical characterization of the prepared MSK film dressings were examined with scanning electron microscopy (SEM) and Fourier-Transform Infrared Spectroscopy (FTIR), respectively. The absorption of pseudo-wound exudate and water vapor transmission rate (WVTR) of film dressings were evaluated.

Results: The results showed that 40% of MSKC film dressing had the highest inhibition zone (20.00 ± 0.00 mm against S. aureus and 17.00 ± 1.00 mm against P. aeruginosa) and 20%, 30%, and 40% of MSKC and MSKN film dressings had inhibition zones similar to nanocrystalline silver dressing for both S. aureus and P. aeruginosa ( p > 0.05). In addition, all concentrations of the MSK film dressings had low absorption capacity, and Chokanan MSK (MSKC) film dressings had a higher WVTR than Namdokmai MSK (MSKN) film dressings.

Conclusion: 20%, 30%, and 40% of MSK film dressing is nearly as effective as nanocrystalline silver dressing. Therefore, it has the potential to be an alternative antibacterial dressing and is suitable for wounds with low exudate levels.

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Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It

Zeinab Breijyeh, Buthaina Jubeh, Rafik Karaman (2020)

Antimicrobial resistance represents an enormous global health crisis and one of the most serious threats humans face today. Some bacterial strains have acquired resistance to nearly all antibiotics. Therefore, new antibacterial agents are crucially needed to overcome resistant bacteria. In 2017, the World Health Organization (WHO) has published a list of antibiotic-resistant priority pathogens, pathogens which present a great threat to humans and to which new antibiotics are urgently needed the list is categorized according to the urgency of need for new antibiotics as critical, high, and medium priority, in order to guide and promote research and development of new antibiotics. The majority of the WHO list is Gram-negative bacterial pathogens. Due to their distinctive structure, Gram-negative bacteria are more resistant than Gram-positive bacteria, and cause significant morbidity and mortality worldwide. Several strategies have been reported to fight and control resistant Gram-negative bacteria, like the development of antimicrobial auxiliary agents, structural modification of existing antibiotics, and research into and the study of chemical structures with new mechanisms of action and novel targets that resistant bacteria are sensitive to. Research efforts have been made to meet the urgent need for new treatments; some have succeeded to yield activity against resistant Gram-negative bacteria by deactivating the mechanism of resistance, like the action of the β-lactamase Inhibitor antibiotic adjuvants. Another promising trend was by referring to nature to develop naturally derived agents with antibacterial activity on novel targets, agents such as bacteriophages, DCAP(2-((3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)amino)-2(hydroxymethyl)propane1,3-diol, Odilorhabdins (ODLs), peptidic benzimidazoles, quorum sensing (QS) inhibitors, and metal-based antibacterial agents.

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Chronic wound infections: the role of Pseudomonas aeruginosa and Staphylococcus aureus.

Raffaele Serra, Raffaele Grande, Lucia Butrico … (2015)

Chronic leg ulcers affect 1-2% of the general population and are related to increased morbidity and health costs. Staphylococcus aureus and Pseudomonas aeruginosa are the most common bacteria isolated from chronic wounds. They can express virulence factors and surface proteins affecting wound healing. The co-infection of S. aureus and P. aeruginosa is more virulent than single infection. In particular, S. aureus and P. aeruginosa have both intrinsic and acquired antibiotic resistance, making clinical management of infection a real challenge, particularly in patients with comorbidity. Therefore, a correct and prompt diagnosis of chronic wound infection requires a detailed knowledge of skin bacterial flora. This is a necessary prerequisite for tailored pharmacological treatment, improving symptoms, and reducing side effects and antibiotic resistance.

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A comparative study of the cytotoxicity of silver-based dressings in monolayer cell, tissue explant, and animal models.

Andrew Burd, Chi Kwok, Siu C Hung … (2015)

Over the past decade, a variety of advanced silver-based dressings have been developed. There are considerable variations in the structure, composition, and silver content of these new preparations. In the present study, we examined five commercially available silver-based dressings (Acticoat, Aquacel Ag, Contreet Foam, PolyMem Silver, Urgotul SSD). We assessed their cytotoxicity in a monolayer cell culture, a tissue explant culture model, and a mouse excisional wound model. The results showed that Acticoat, Aquacel Ag, and Contreet Foam, when pretreated with specific solutes, were likely to produce the most significant cytotoxic effects on both cultured keratinocytes and fibroblasts, while PolyMem Silver and Urgotul SSD demonstrated the least cytotoxicity. The cytotoxicity correlated with the silver released from the dressings as measured by silver concentration in the culture medium. In the tissue explant culture model, in which the epidermal cell proliferation was evaluated, all silver dressings resulted in a significant delay of reepithelialization. In the mouse excisional wound model, Acticoat and Contreet Foam indicated a strong inhibition of wound reepithelialization on the postwounding-day 7. These findings may, in part, explain the clinical observations of delayed wound healing or inhibition of wound epithelialization after the use of certain topical silver dressings. Caution should be exercised in using silver-based dressings in clean superficial wounds such as donor sites and superficial burns and also when cultured cells are being applied to wounds.

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Author and article information

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Sukhontha Hasatsri: URI : https://loop.frontiersin.org/people/2623317/overview

Journal

Journal ID (nlm-ta): J Pharm Pharm Sci

Journal ID (iso-abbrev): J Pharm Pharm Sci

Journal ID (publisher-id): J. Pharm. Pharm. Sci

Title: Journal of Pharmacy & Pharmaceutical Sciences

Publisher: Frontiers Media S.A.

ISSN (Electronic): 1482-1826

Publication date (Electronic): 28 March 2024

Publication date Collection: 2024

Volume: 27

Electronic Location Identifier: 12674

Affiliations

[1] ¹ Department of Pharmacy Practice , College of Pharmacy , Rangsit University , Pathum Thani, Thailand

[2] ² Faculty of Medical Technology , Rangsit University , Pathum Thani, Thailand

Author notes

Edited by: Fakhreddin Jamali, University of Alberta, Canada

*Correspondence: Sukhontha Hasatsri, sukhontha.h@ 123456rsu.ac.th

Article

Publisher ID: 12674

DOI: 10.3389/jpps.2024.12674

PMC ID: 11006813

PubMed ID: 38606395

SO-VID: 194baa6e-6125-461c-b91d-cdf76e86061b

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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

History

Date received : 09 January 2024

Date accepted : 15 March 2024

Funding

Funded by: Rangsit University , doi 10.13039/501100007939;

This research was funded by the College of Pharmacy, Rangsit University, Thailand.

Film dressings from Thai mango seed kernel extracts versus nanocrystalline silver dressings in antibacterial properties

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Most cited references 38

Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It

Chronic wound infections: the role of Pseudomonas aeruginosa and Staphylococcus aureus.

A comparative study of the cytotoxicity of silver-based dressings in monolayer cell, tissue explant, and animal models.

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