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Abstract
Patient-reported outcomes (PROs) are increasingly used in multiple sclerosis (MS)
research and clinical practice for understanding the effects that the disease and
its treatments have on patients' lives. PROs are captured directly from patients and
include symptoms, function, health status, and health-related quality of life. No
universal guidance on appropriateness of each applied tool exists. However, collecting
clear and comprehensive outcome measures represents the first step of patient centered
therapeutic management. The importance of PRO assessment is expected to continue to
grow in the future. But in current MS reality, PROs are selected and used without
a clear justification, and only few PROs are of adequate psychometric quality. There
is a clear need for the development of high-quality; MS-specific PROs that assess
the true concerns of patients and that evaluate the impact of both clinical and non-clinical
interventions on a variety of outcomes. In this perspective review, we describe the
importance of and methods for using PRO in MS by defining and identifying the used
PROs in MS. Moreover, we will outline the challenges and key unanswered questions
for routine use of PROs in MS discussing potential interventions to accelerate the
integration of PROs in the clinical management of MS.