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      Care priorities for stroke patients developing cognitive difficulties: a Delphi survey of UK professional views

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          Abstract

          Background

          Post stroke cognitive difficulties are common but generally prioritised below other impairments. In the UK, clinical guidelines recommend a holistic review at six-months post-stroke including an assessment of cognitive function. In order to assist clinicians to provide better care for patients with post-stroke cognitive deficits and assist with service planning, our aim was to establish professional consensus on key actions at the six-month review.

          Methods

          An electronic Delphi survey was developed with ten potential actions for clinicians to prioritise across five different clinical scenarios describing patients with cognitive difficulties. Scenarios varied in terms of age of the stroke-survivor, stroke severity and use of dementia risk assessment. A panel of professional volunteers was obtained through the British Association of Stroke Physicians and the UK National Stroke Nursing Forum.

          Results

          Forty-five stroke clinicians completed round one, with 21 participants completing round two. Priorities consistently supported by professionals included access to psychological services, screening for a mood disorder and ensuring multi-professional input. Direct access to specialist memory services was not generally supported unless a dementia risk assessment tool indicated that the individual was at high risk of dementia.

          Conclusions

          Assessment of post-stroke cognitive deficits needs to be routinely considered during the six-month review. A formal risk assessment tool could be a way to streamline direct access to memory clinic services to ensure that individuals at-risk of dementia receive ongoing care.

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          Most cited references20

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          Economic burden of stroke: a systematic review on post-stroke care

          Stroke is a leading cause for disability and morbidity associated with increased economic burden due to treatment and post-stroke care (PSC). The aim of our study is to provide information on resource consumption for PSC, to identify relevant cost drivers, and to discuss potential information gaps.
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            Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease.

            High blood pressure and stroke are associated with increased risks of dementia and cognitive impairment. This study aimed to determine whether blood pressure lowering would reduce the risks of dementia and cognitive decline among individuals with cerebrovascular disease. The Perindopril Protection Against Recurrent Stroke Study (PROGRESS) was a randomized, double-blind, placebo-controlled trial conducted among 6105 people with prior stroke or transient ischemic attack. Participants were assigned to either active treatment (perindopril for all participants and indapamide for those with neither an indication for nor a contraindication to a diuretic) or matching placebo(s). The primary outcomes for these analyses were dementia (using DSM-IV criteria) and cognitive decline (a decline of 3 or more points in the Mini-Mental State Examination score). During a mean follow-up of 3.9 years, dementia was documented in 193 (6.3%) of the 3051 randomized participants in the actively treated group and 217 (7.1%) of the 3054 randomized participants in the placebo group (relative risk reduction, 12% [95% confidence interval, -8% to 28%]; P =.2). Cognitive decline occurred in 9.1% of the actively treated group and 11.0% of the placebo group (risk reduction, 19% [95% confidence interval, 4% to 32%]; P =.01). The risks of the composite outcomes of dementia with recurrent stroke and of cognitive decline with recurrent stroke were reduced by 34% (95% confidence interval, 3% to 55%) (P =.03) and 45% (95% confidence interval, 21% to 61%) (P<.001), respectively, with no clear effect on either dementia or cognitive decline in the absence of recurrent stroke. Active treatment was associated with reduced risks of dementia and cognitive decline associated with recurrent stroke. These findings further support the recommendation that blood pressure lowering with perindopril and indapamide therapy be considered for all patients with cerebrovascular disease.
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              Stroke and dementia risk: A systematic review and meta-analysis

              INTRODUCTION: Stroke is an established risk factor for all-cause dementia, though meta-analyses are needed to quantify this risk. METHODS: We searched Medline, PsycINFO and Embase for studies assessing prevalent or incident stroke versus a no-stroke comparison group and the risk of all-cause dementia. Random effects meta-analysis was used to pool adjusted estimates across studies and meta-regression was used to investigate potential effect modifiers. RESULTS: We identified 36 studies of prevalent stroke (1.9 million participants) and 12 studies of incident stroke (1.3 million participants). For prevalent stroke, the pooled hazard ratio for all-cause dementia was 1.69 (95% CI: 1.49–1.92; p<0.00001; I 2 = 87%). For incident stroke, the pooled risk ratio was 2.18 (95% CI: 1.90–2.50; p<0.00001; I 2 = 88%). Study characteristics did not modify these associations, with the exception of sex which explained 50.2% of between-study heterogeneity for prevalent stroke. DISCUSSION: Stroke is a strong, independent, and potentially modifiable risk factor for all-cause dementia.
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                Author and article information

                Contributors
                e.y.h.tang@newcastle.ac.uk
                a.l.robinson@newcastle.ac.uk
                catherine.exley@newcastle.ac.uk
                d.flynn@tees.ac.uk
                blossom.stephan@nottingham.ac.uk
                c.i.m.price@newcastle.ac.uk
                Journal
                BMC Health Serv Res
                BMC Health Serv Res
                BMC Health Services Research
                BioMed Central (London )
                1472-6963
                5 August 2020
                5 August 2020
                2020
                : 20
                : 717
                Affiliations
                [1 ]GRID grid.1006.7, ISNI 0000 0001 0462 7212, Population Health Sciences Institute, Newcastle University, Campus for Ageing and Vitality, ; Level 2, Newcastle Biomedical Research Building, Newcastle upon Tyne, NE4 5PL UK
                [2 ]GRID grid.26597.3f, ISNI 0000 0001 2325 1783, Centre for Rehabilitation, Exercise and Sports Science, , School of Health & Life Sciences, Teesside University, ; Middlesbrough Tees Valley, TS1 3BX UK
                [3 ]GRID grid.4563.4, ISNI 0000 0004 1936 8868, Division of Psychiatry and Applied Psychology, , Institute of Mental Health, School of Medicine, University of Nottingham, ; Innovation Park, Nottingham, NG7 2TU UK
                Author information
                http://orcid.org/0000-0003-1030-9311
                Article
                5558
                10.1186/s12913-020-05558-y
                7404922
                19f7ed88-8c52-4234-a477-cc299d362ccd
                © The Author(s) 2020

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                : 19 December 2019
                : 20 July 2020
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100000272, National Institute for Health Research;
                Award ID: DRF-2015-08-006
                Award ID: NF-SI-0616-10054
                Award Recipient :
                Funded by: FundRef http://dx.doi.org/10.13039/501100000364, Stroke Association;
                Award ID: TSA LECT 2017/03
                Award Recipient :
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2020

                Health & Social care
                stroke,cognition,risk assessment,dementia,delphi
                Health & Social care
                stroke, cognition, risk assessment, dementia, delphi

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