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      Association of Endothelial Nitric Oxide Synthase Gene Polymorphism with Susceptibility and Nephritis Development of Henoch-Schönlein Purpura in Chinese Han Children.

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          Abstract

          Henoch-Schönlein purpura (HSP) is the most common form of systemic small-vessel vasculitis in children. Previous studies suggested endothelial nitric oxide synthase (eNOS) plays an important role in the pathogenesis and clinical manifestations of HSP. This study aimed to investigate the potential association between 10 single-nucleotide polymorphisms (SNPs) within the eNOS gene and HSP risk and nephritis development in a Chinese Han population.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Genet Test Mol Biomarkers
          Title: Genetic testing and molecular biomarkers
          Publisher: Mary Ann Liebert Inc
          ISSN (Electronic): 1945-0257
          ISSN (Print): 1945-0257
          Publication date (Electronic): Jun 2017
          Volume: 21
          Issue: 6
          Affiliations
          [1 ] 1 Department of Pediatrics, Baoji City Chinese Medicine Hospital , Baoji, P.R. China .
          [2 ] 2 Department of Internal Medicine, Guo Town Hospital of Chencang District , Baoji, P.R. China .
          [3 ] 3 Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, P.R. China .
          Article
          DOI: 10.1089/gtmb.2016.0213
          PubMed ID: 28409662
          SO-VID: 1a217eb1-bc15-4e1a-8ca5-a35dc8534c2e
          History

          Keywords: Chinese Han population,Henoch–Schönlein purpura,Henoch–Schönlein purpura nephritis,endothelial nitric oxide synthase,single-nucleotide polymorphism
          Data availability:
          Keywords: Chinese Han population, Henoch–Schönlein purpura, Henoch–Schönlein purpura nephritis, endothelial nitric oxide synthase, single-nucleotide polymorphism

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