Automatic, localizedin Vivo adjustment of all first-and second-order shim coils

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Abstract

The implementation of a "fast, automatic shimming technique by mapping along projections" (FASTMAP) on a 2.1-Tesla whole-body system is described. The method provides a localized adjustment of all first- (X, Y, Z) and second-order (Z2, ZX, ZY, X2-Y2, 2XY) coils in 2 min. The time savings are achieved by mapping the magnetic field along six projections rather than from whole-imaging data sets. An analysis of noise error propagation suggests that in 64-ml volumes the residual linewidths obtained with the method are negligible when the signal-to-rms-noise ratio is above 30. The initial application of the method to localized 13C, 31P, and 1H spectroscopy of the human brain resulted in linewidths of approximately 2 Hz for 13C (144-ml volume), approximately 2.5 Hz for 31P (36-ml volume) and approximately 4 Hz for 1H (36-ml volume) with symmetric and reproducible lineshapes.

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Most cited references 12

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Magnet field profiling: analysis and correcting coil design.

D I Hoult, F. Romeo (1984)

A full mathematical framework for the analysis and production of localized magnetic field profiles is presented. Of primary use in the production of highly homogeneous fields for nuclear magnetic resonance studies, the paper details the analysis of fields in terms of spherical harmonics, describes how field plotting in the appropriate manner may be used to obtain a direct measure of which harmonics are present, and shows how to combine basic "building blocks" to produce the various lower-order zonal and tesseral harmonics. "Building blocks" described include coils, arcs, and sinusoids of current as well as rings and arcs of steel. The use of shaped magnets is also briefly mentioned. Attention is drawn to the presence, in high-order designs, of possibly dominant lower orders of harmonics created by errors in fabrication. The goal of the paper is to present a design philosophy, backed by the appropriate mathematics, which is applicable to the variety of situations encountered in magnet design. Practical examples of correcting coils and "shims" are also given.

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Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy.

R Gruetter, E. Novotny, S D Boulware … (1992)

Glucose is the main fuel for energy metabolism in the normal human brain. It is generally assumed that glucose transport into the brain is not rate-limiting for metabolism. Since brain glucose concentrations cannot be determined directly by radiotracer techniques, we used 13C NMR spectroscopy after infusing enriched D-[1-13C]glucose to measure brain glucose concentrations at euglycemia and at hyperglycemia (range, 4.5-12.1 mM) in six healthy children (13-16 years old). Brain glucose concentrations averaged 1.0 +/- 0.1 mumol/ml at euglycemia (4.7 +/- 0.3 mM plasma) and 1.8-2.7 mumol/ml at hyperglycemia (7.3-12.1 mM plasma). Michaelis-Menten parameters of transport were calculated to be Kt = 6.2 +/- 1.7 mM and Tmax = 1.2 +/- 0.1 mumol/g.min from the relationship between plasma and brain glucose concentrations. The brain glucose concentrations and transport constants are consistent with transport not being rate-limiting for resting brain metabolism at plasma levels greater than 3 mM.