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      Uncovering the unmet needs among psoriasis patients in the Asia‐Pacific region

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          Abstract

          Studies on the psychosocial and emotional burden of psoriasis have been extensive; however, there is limited knowledge and awareness of patients’ attitude and behavior towards psoriasis treatment. To understand psoriasis patients’ attitude and behavior towards treatment of psoriasis, especially those treated with biologics, a multi‐stage study qualitative and quantitative methodology was conducted among psoriasis patients. An online survey was conducted with 45 moderate‐to‐severe psoriasis patients each in Australia, Japan, South Korea, and Taiwan for 20 min. This was followed by qualitative in‐depth interviews conducted among psoriasis patients in Australia (n = 3) and Japan (n = 2) for 60 min. All of the findings were workshopped with key opinion leaders and patient advisory groups to identify potential solutions addressing patients’ unmet needs. Five common insights were identified across the region, highlighting patients’ attitude and behavior towards psoriasis treatment, especially for those treated with biologics. These insights comprised the following: (i) one of the key factors driving patients’ treatment choice included their ability to enjoy clear skin for longer period (68%); (ii) bio‐maintenance patients had a higher expectation (4.9 months) of how long their skin could stay clear, compared to their pre‐biologics initiation days (2.9 months); (iii) once a good response is achieved, bio‐maintenance patients were more concerned about symptoms returning (44%) than development of side‐effects (19%); (iv) bio‐maintenance patients felt psychologically and physically affected during flare‐ups despite being on more efficacious treatment; and (v) bio‐maintenance patients still felt they were at risk of flare‐ups (4.5/7), almost similar risk perception as non‐biologics patients (4.9/7). Findings from this study showed that psoriasis patients look for treatment with the least risk of flare‐ups so that they were able to enjoy clear skin for a long time.

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          Global epidemiology of psoriasis: a systematic review of incidence and prevalence.

          The worldwide incidence and prevalence of psoriasis is poorly understood. To better understand this, we performed a systematic review of published population-based studies on the incidence and prevalence of psoriasis. Three electronic databases were searched from their inception dates to July 2011. A total of 385 papers were critically appraised; 53 studies reported on the prevalence and incidence of psoriasis in the general population. The prevalence in children ranged from 0% (Taiwan) to 2.1% (Italy), and in adults it varied from 0.91% (United States) to 8.5% (Norway). In children, the incidence estimate reported (United States) was 40.8/100,000 person-years. In adults, it varied from 78.9/100,000 person-years (United States) to 230/100,000 person-years (Italy). The data indicated that the occurrence of psoriasis varied according to age and geographic region, being more frequent in countries more distant from the equator. Prevalence estimates also varied in relation to demographic characteristics in that studies confined to adults reported higher estimates of psoriasis compared with those involving all age groups. Studies on the prevalence and incidence of psoriasis have contributed to a better understanding of the burden of the disease. However, further research is required to fill existing gaps in understanding the epidemiology of psoriasis and trends in incidence over time.
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            Epidemiology of psoriasis and palmoplantar pustulosis: a nationwide study using the Japanese national claims database

            Objective The primary objective was to estimate the national prevalence of psoriasis and palmoplantar pustulosis (PPP) in Japan. Secondary objectives were to determine (1) whether psoriasis and PPP disease activity varies by season, and (2) whether disease severity is associated with concurrent diabetes mellitus, hyperlipidaemia and hypertension. Settings Patients with a psoriasis or PPP diagnosis code between April 2010 and March 2011 were identified using a Japanese national database. Participants 565 903 patients with psoriasis or PPP were identified. No patient was excluded. Primary and secondary outcome measures National prevalence was calculated using census data. We estimated the difference in the proportion of patients who used healthcare services, as a proxy for disease activity, between the hot and cold seasons and the difference in the standardised prevalence of comorbidities between severe and mild disease. The measures were estimated separately for the two broad disease categories of psoriasis and PPP but not in all patients as planned because the two disease categories had major differences. Results The national prevalence of psoriasis and PPP was 0.34% (95% CI 0.34% to 0.34%) and 0.12% (0.12% to 0.12%), respectively. The difference in the proportion of patients who used healthcare services in the hot compared to the cold season was −0.3% (−0.5% to −0.1%) for psoriasis and 10.0% (9.8% to 10.3%) for PPP. The difference in the standardised prevalence between severe and mild psoriasis was 3.1% (2.7% to 3.4%), 3.2% (2.8% to 3.6%) and 5.1% (4.7% to 5.6%) for concurrent diabetes mellitus, hyperlipidaemia and hypertension, respectively. No significant difference in the prevalence of comorbidity was observed for PPP. Conclusions The national prevalence, seasonal variation in disease activity and prevalence of comorbidities in Japanese patients with psoriasis and PPP estimated in this descriptive study may be used as basic information for future studies.
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              Undertreatment, treatment trends, and treatment dissatisfaction among patients with psoriasis and psoriatic arthritis in the United States: findings from the National Psoriasis Foundation surveys, 2003-2011.

              Psoriasis and psoriatic arthritis inflict significant morbidity. Data on undertreatment, treatment use, and treatment satisfaction are paramount to identify priority areas for advocacy, education, and research to improve patient outcomes.
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                Author and article information

                Contributors
                pablo.fernandezpenas@sydney.edu.au
                Journal
                J Dermatol
                J Dermatol
                10.1111/(ISSN)1346-8138
                JDE
                The Journal of Dermatology
                John Wiley and Sons Inc. (Hoboken )
                0385-2407
                1346-8138
                27 July 2021
                November 2021
                : 48
                : 11 ( doiID: 10.1111/jde.v48.11 )
                : 1665-1674
                Affiliations
                [ 1 ] Department of Dermatology Teikyo University School of Medicine Tokyo Japan
                [ 2 ] Department of Dermatology Seoul National University College of Medicine Seoul South Korea
                [ 3 ] Department of Dermatology Chang Gung Memorial Hospital Taoyuan Taiwan
                [ 4 ] Janssen Asia Pacific Singapore City Singapore
                [ 5 ] Kantar Health Singapore City Singapore
                [ 6 ] Sydney Medical School The University of Sydney Sydney New South Wales Australia
                [ 7 ] Department of Dermatology Westmead Hospital Westmead New South Wales Australia
                Author notes
                [*] [* ] Correspondence

                Pablo Fernández‐Peñas, Sydney Medical School, Department of Dermatology, Westmead Hospital, Cnr Hawkesbury Road and Darcy Rd, Westmead NSW 2145, Australia.

                Email: pablo.fernandezpenas@ 123456sydney.edu.au

                Author information
                https://orcid.org/0000-0001-6016-8209
                https://orcid.org/0000-0003-4882-1564
                Article
                JDE16072
                10.1111/1346-8138.16072
                9290722
                34318497
                1c43787f-4631-420a-9cb0-7db672db0697
                © 2021 The Authors. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Dermatological Association

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

                History
                : 03 June 2021
                : 13 March 2021
                : 05 July 2021
                Page count
                Figures: 4, Tables: 2, Pages: 10, Words: 5079
                Funding
                Funded by: Janssen Asia‐Pacific
                Categories
                Original Article
                Original Articles
                Custom metadata
                2.0
                November 2021
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.1.7 mode:remove_FC converted:18.07.2022

                biologics,flare‐ups,psoriasis,psoriasis treatment,quality of life

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