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      Resection of a thoracoabdominal ganglioneuroma via a retroperitoneal minimally invasive approach

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          Abstract

          A 10-year-old girl presented to her pediatrician with a history of cough and fever. A chest radiograph revealed a paraspinal mass. On cross-sectional imaging, the mass traversed the diaphragm, extending from T9 to L1 spinal levels with involvement of the T10–12 neural foramen. Vanillylmandelic and homovanillic acid levels were normal. On review of historical radiographs, the mass had increased in size. Thus, surgical resection was recommended for diagnosis and treatment.

          The patient was placed in left lateral decubitus position. The retroperitoneal space was accessed inferior to the twelfth rib. One 12 mm and two 5 mm ports were used. Development of the retroperitoneal space was achieved with both blunt dissection and a vessel-sealing device. The diaphragm was incised to resect the thoracic component of the mass. The tumor was adherent at the neural foramen and was resected flush with the spine. The diaphragm repaired primarily. She was discharged home on post-operative day four without complication. Pathology demonstrated a ganglioneuroma. The patient was well at her follow-up, and imaging one year postoperatively was without recurrence. No additional treatment was required.

          A laparoscopic retroperitoneal approach allows for a safe, minimally invasive resection of a thoracoabdominal mass without violation of the abdominal cavity.

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          Pediatric retroperitoneal laparoscopic partial nephrectomy: comparison with an age matched cohort of open surgery.

          We assessed the clinical usefulness of laparoscopic retroperitoneal partial nephrectomy (LRPN) in children by comparing an age matched cohort of pediatric patients undergoing open partial nephrectomy (OPN) to those undergoing LRPN for safety, efficacy, operative time, blood loss, inpatient narcotic use and length of hospitalization. A retrospective case-control study was performed of 1 group undergoing LRPN (treatment arm) and 1 undergoing OPN (controls) between 1997 and 2003. The 14 patients in each group were matched by age (mean 1.9 years in LRPN group vs 2.2 years in OPN group, p = 0.98) and gender. All patients had duplication anomalies. Mean operative time was 194 minutes in the LRPN group and 193 minutes in the OPN group (p = 0.83). The single complication in the LRPN group was a urinoma that did not require intervention. There were no complications in OPN group. LRPN patients had a mean hospitalization of 1.7 days compared to 4.7 days in OPN patients (p = 0.001). Intraoperative narcotic requirements were higher in the LRPN group (0.59 vs 0.22 mg/kg, p = 0.04). Postoperative narcotic requirements were significantly less in the LRPN group (0.44 vs 1.53 mg/kg, p = 0.04). Similar findings were noted in a subanalysis of patients younger than 2 years. All patients had documented postoperative ipsilateral renal growth. Mean followups in the treatment and control groups were 26 and 25 months, respectively. Retroperitoneal laparoscopic partial nephrectomy in small children was shown to be safe and effective. It had equivalent operative times, and decreased postoperative narcotics and hospitalization relative to the open approach, and, therefore, is a potentially advantageous technique.
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            Laparoscopic resection of nonadrenal retroperitoneal tumors.

            Laparoscopic resection of primary retroperitoneal tumors is a challenging procedure because access is difficult due to the deep, posterior location and adjacent major vessels. To assess the safety and feasibility of laparoscopic resection of primary nonadrenal retroperitoneal tumors. Method  Data on 20 patients with a diagnosis of primary retroperitoneal tumor who underwent laparoscopic resection from August 1, 2003, to June 30, 2009 were analyzed. Twenty patients (12 men and 8 women; median age, 45.5 years) were included in the review. The tumor sizes ranged from 2.0 to 9.5 cm in diameter (median, 4.7 cm). In 10 patients, tumors were adherent to adjacent major vessels (ie, inferior vena cava, renal vein, superior mesenteric vein, or the splenic vessel). Postoperative examination of the samples revealed that lymphangioma (7 [35.0%]) was the most common tumor type, followed by ganglioneuroma (3 [15.0%]), schwannoma (2 [10.0%]), paragangolioma (2 [10.0%]), and Castleman disease (2 [10.0%]). The median operative time was 117.5 minutes and the median estimated blood loss was 50.0 mL. One operation (0.05%) was converted to laparotomy due to intraoperative bleeding. Postoperative complications occurred in 2 patients (10.0%), both of whom were treated conservatively. The median length of the postoperative hospital stay was 5 days. Neither tumor size nor the presence of adhesions to adjacent vessels affected the perioperative or clinical outcomes. Laparoscopic resection of retroperitoneal tumors is feasible even when a tumor is large or adheres to adjacent vascular structures if there is no evidence of malignancy based on preoperative radiologic studies.
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              Two cases of ganglioneuroma.

              Although ganglioneuroma is a relatively rare tumor of the sympathetic nervous system, detection of this tumor has increased as imaging techniques such as computed tomography and ultrasonography have become prevalent. We report 2 cases of ganglioneuroma found incidentally. Both tumors were 40 to 60 mm in size. Magnetic resonance imaging in 1 patient showed a homogeneous mass with a low signal intensity on T1-weighted imaging and a heterogeneous mass with a high signal intensity on T2-weighted imaging, both characteristic of neurogenic tumor. Therefore, we performed laparoscopic adrenalectomy. Histopathologic examination demonstrated that one tumor was located on the adrenal medulla, with the other in the extra-adrenal retroperitoneal space.
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                Author and article information

                Journal
                101628383
                42401
                J Pediatr Surg Case Rep
                J Pediatr Surg Case Rep
                Journal of pediatric surgery case reports
                2213-5766
                22 February 2019
                25 October 2018
                January 2019
                19 November 2019
                : 40
                : 47-49
                Affiliations
                University of California – Davis, Division of Pediatric General, Thoracic and Fetal Surgery, USA
                Author notes

                Authorship

                All authors attest that they meet the current ICMJE criteria for Authorship.

                [* ]Corresponding author. University of California – Davis, Division of Pediatric General, Thoracic and Fetal Surgery, 2425 Stockton Blvd., Room 517, Sacramento, CA 95817, USA. lgalganski@ 123456ucdavis.edu (L.A. Galganski).
                Article
                NIHMS1013565
                10.1016/j.epsc.2018.10.012
                6863619
                31745453
                1c9594fa-1973-4333-8b97-7b549d288f7e

                This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/BY-NC-ND/4.0/).

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                Article

                pediatric laparoscopic,retroperitoneoscopic,ganglioneuroma,ganglioneuroblastoma,neuroblastoma,thoracoabdominal resection

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