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      Common Fundamentals of Psoriasis and Depression

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          Abstract

          Psoriasis is an inflammatory, immune-mediated disease that is frequently associated with psychological comorbidities such as depression. The stigma patients feel because of the appearance of their skin may contribute to the high psycho-social burden of psoriasis. However, there is emerging evidence that overlapping biological mechanisms are, to a substantial degree, responsible for the close interaction between psoriasis and depression. Increased proinflammatory mediators, such as C-reactive protein or interleukin-6, are present in both psoriasis and depression, indicating that inflammation may represent a pathophysiological link between the diseases. Anti-inflammatory biologic therapies treat the clinical manifestations of psoriasis, but might also play a significant role in reducing associated depressive symptoms in patients with psoriasis. Comparison between single studies focusing on the change in depressive symptoms in psoriasis is limited by inconsistency in the depression screening tools applied.

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          The role of inflammation in depression: from evolutionary imperative to modern treatment target.

          Andrew Miller, Charles L. Raison (2016)
          Crosstalk between inflammatory pathways and neurocircuits in the brain can lead to behavioural responses, such as avoidance and alarm, that are likely to have provided early humans with an evolutionary advantage in their interactions with pathogens and predators. However, in modern times, such interactions between inflammation and the brain appear to drive the development of depression and may contribute to non-responsiveness to current antidepressant therapies. Recent data have elucidated the mechanisms by which the innate and adaptive immune systems interact with neurotransmitters and neurocircuits to influence the risk for depression. Here, we detail our current understanding of these pathways and discuss the therapeutic potential of targeting the immune system to treat depression.
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            From inflammation to sickness and depression: when the immune system subjugates the brain.

            Robert Dantzer, Jason O'Connor, Gregory Freund … (2008)
            In response to a peripheral infection, innate immune cells produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour. When activation of the peripheral immune system continues unabated, such as during systemic infections, cancer or autoimmune diseases, the ensuing immune signalling to the brain can lead to an exacerbation of sickness and the development of symptoms of depression in vulnerable individuals. These phenomena might account for the increased prevalence of clinical depression in physically ill people. Inflammation is therefore an important biological event that might increase the risk of major depressive episodes, much like the more traditional psychosocial factors.
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              Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies.

              Floriana Luppino, Leonore de Wit, Paul Bouvy … (2010)
              Association between obesity and depression has repeatedly been established. For treatment and prevention purposes, it is important to acquire more insight into their longitudinal interaction. To conduct a systematic review and meta-analysis on the longitudinal relationship between depression, overweight, and obesity and to identify possible influencing factors. Studies were found using PubMed, PsycINFO, and EMBASE databases and selected on several criteria. Studies examining the longitudinal bidirectional relation between depression and overweight (body mass index 25-29.99) or obesity (body mass index > or =30) were selected. Unadjusted and adjusted odds ratios (ORs) were extracted or provided by the authors. Overall, unadjusted ORs were calculated and subgroup analyses were performed for the 15 included studies (N = 58 745) to estimate the effect of possible moderators (sex, age, depression severity). Obesity at baseline increased the risk of onset of depression at follow-up (unadjusted OR, 1.55; 95% confidence interval [CI], 1.22-1.98; P or =60 years) but not among younger persons (aged <20 years). Baseline depression (symptoms and disorder) was not predictive of overweight over time. However, depression increased the odds for developing obesity (OR, 1.58; 95% CI, 1.33-1.87; P < .001). Subgroup analyses did not reveal specific moderators of the association. This meta-analysis confirms a reciprocal link between depression and obesity. Obesity was found to increase the risk of depression, most pronounced among Americans and for clinically diagnosed depression. In addition, depression was found to be predictive of developing obesity.
              Article 0 comments Cited 674 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Acta Derm Venereol
                Journal ID (iso-abbrev): Acta Derm Venereol
                Journal ID (publisher-id): ActaDV
                Title: Acta Dermato-Venereologica
                Publisher: Society for Publication of Acta Dermato-Venereologica
                ISSN (Print): 0001-5555
                ISSN (Electronic): 1651-2057
                Publication date (Electronic): 30 November 2021
                Publication date Collection: 2021
                Volume: 101
                Issue: 11
                Electronic Location Identifier: 565
                Affiliations
                [1 ]Institute of Medical Psychology and Behavioral Immunobiology
                [2 ]Department of Dermatology, Venereology and Allergology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
                [3 ]Department of Clinical Neuroscience, Osher Center for Integrative Medicine, Karolinska Institutet, Stockholm, Sweden
                Author notes
                Corr: Wiebke Sondermann, Department of Dermatology, Venereology and Allergology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, DE-45122 Essen, Germany. E-mail: wiebke.sonder-mann@ 123456uk-essen.de
                [#]

                Both authors contributed equally

                Article
                Publisher ID: ActaDV-101-11-565
                DOI: 10.2340/actadv.v101.565
                PMC ID: 9455336
                PubMed ID: 34806760
                SO-VID: 1cad2b42-9945-4da8-b655-0e201b140980
                Copyright © © 2021 Acta Dermato-Venereologica
                License:

                This is an open access article under the CC BY-NC license

                History
                Date accepted : 22 November 2021
                Categories
                Subject: Review Article

                Keywords: psoriasis,depression,psychological comorbidity,inflammation,pathophysiological link,depression screening tools
                Data availability:
                Keywords: psoriasis, depression, psychological comorbidity, inflammation, pathophysiological link, depression screening tools

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