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      White Matter Tissue Quantification at Low b-Values Within Constrained Spherical Deconvolution Framework

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          Abstract

          In the last decades, a number of Diffusion Weighted Imaging (DWI) based techniques have been developed to study non-invasively human brain tissues, especially white matter (WM). In this context, Constrained Spherical Deconvolution (CSD) is recognized as being able to accurately characterize water molecules displacement, as they emerge from the observation of MR diffusion weighted (MR-DW) images. CSD is suggested to be applied on MR-DW datasets consisting of b-values around 3,000 s/mm 2 and at least 45 unique diffusion weighting directions. Below such technical requirements, Diffusion Tensor Imaging (DT) remains the most widely accepted model. Unlike CSD, DTI is unable to resolve complex fiber geometries within the brain, thus affecting related tissues quantification. In addition, thanks to CSD, an index called Apparent Fiber Density (AFD) can be measured to estimate intra-axonal volume fraction within WM. In standard clinical settings, diffusion based acquisitions are well below such technical requirements. Therefore, in this study we wanted to extensively compare CSD and DTI model outcomes on really low demanding MR-DW datasets, i.e., consisting of a single shell ( b-value = 1,000 s/mm 2) and only 30 unique diffusion encoding directions. To this end, we performed deterministic and probabilistic tractographic reconstruction of two major WM pathways, namely the Corticospinal Tract and the Arcuate Fasciculus. We estimated and analyzed tensor based features as well as, for the first time, AFD interpretability in our data. By performing multivariate statistics and tract-based ROI analysis, we demonstrate that WM quantification is affected by both the diffusion model and threshold applied to noisy tractographic maps. Consistently with existing literature, we showed that CSD outperforms DTI even in our scenario. Most importantly, for the first time we address the problem of accuracy and interpretation of AFD in a low-demanding DW setup, and show that it is still a biological meaningful measure for the analysis of intra-axonal volume even in clinical settings.

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          Most cited references 61

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          Characterization and propagation of uncertainty in diffusion-weighted MR imaging.

          A fully probabilistic framework is presented for estimating local probability density functions on parameters of interest in a model of diffusion. This technique is applied to the estimation of parameters in the diffusion tensor model, and also to a simple partial volume model of diffusion. In both cases the parameters of interest include parameters defining local fiber direction. A technique is then presented for using these density functions to estimate global connectivity (i.e., the probability of the existence of a connection through the data field, between any two distant points), allowing for the quantification of belief in tractography results. This technique is then applied to the estimation of the cortical connectivity of the human thalamus. The resulting connectivity distributions correspond well with predictions from invasive tracer methods in nonhuman primate. Copyright 2003 Wiley-Liss, Inc.
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            Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging.

            The relationship between brain structure and complex behavior is governed by large-scale neurocognitive networks. The availability of a noninvasive technique that can visualize the neuronal projections connecting the functional centers should therefore provide new keys to the understanding of brain function. By using high-resolution three-dimensional diffusion magnetic resonance imaging and a newly designed tracking approach, we show that neuronal pathways in the rat brain can be probed in situ. The results are validated through comparison with known anatomical locations of such fibers.
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              In vivo fiber tractography using DT-MRI data.

              Fiber tract trajectories in coherently organized brain white matter pathways were computed from in vivo diffusion tensor magnetic resonance imaging (DT-MRI) data. First, a continuous diffusion tensor field is constructed from this discrete, noisy, measured DT-MRI data. Then a Frenet equation, describing the evolution of a fiber tract, was solved. This approach was validated using synthesized, noisy DT-MRI data. Corpus callosum and pyramidal tract trajectories were constructed and found to be consistent with known anatomy. The method's reliability, however, degrades where the distribution of fiber tract directions is nonuniform. Moreover, background noise in diffusion-weighted MRIs can cause a computed trajectory to hop from tract to tract. Still, this method can provide quantitative information with which to visualize and study connectivity and continuity of neural pathways in the central and peripheral nervous systems in vivo, and holds promise for elucidating architectural features in other fibrous tissues and ordered media.
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                Author and article information

                Affiliations
                1IRCCS Centro Neurolesi Bonino Pulejo , Messina, Italy
                2Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele , Milan, Italy
                3Department of Clinical and Experimental Medicine, University of Messina , Messina, Italy
                4Department of Biomedical Sciences and Morphological and Functional Images, University of Messina , Messina, Italy
                5Fresco Institute for Parkinson's & Movement Disorders, NYU-Langone School of Medicine , New York, NY, United States
                Author notes

                Edited by: Christian Gaser, Friedrich-Schiller-Universität Jena, Germany

                Reviewed by: Mojgan Hodaie, University of Toronto, Canada; Alessia Sarica, Università degli Studi Magna Graecia, Italy

                *Correspondence: Alessandro Calamuneri alecalamuneri@ 123456gmail.com

                This article was submitted to Applied Neuroimaging, a section of the journal Frontiers in Neurology

                †These authors have contributed equally to this work

                Contributors
                Journal
                Front Neurol
                Front Neurol
                Front. Neurol.
                Frontiers in Neurology
                Frontiers Media S.A.
                1664-2295
                28 August 2018
                2018
                : 9
                6122130 10.3389/fneur.2018.00716
                Copyright © 2018 Calamuneri, Arrigo, Mormina, Milardi, Cacciola, Chillemi, Marino, Gaeta and Quartarone.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                Counts
                Figures: 5, Tables: 4, Equations: 2, References: 61, Pages: 14, Words: 9328
                Categories
                Neurology
                Methods

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