The Asteraceae (alt. Compositae) family incorporates a large number of flowering plants, which have been classified under ca. 1600 genera covering more than 23,000 species. The genus Achillea is one of the best-known genera of this family. The Achillea species are important for their uses in the chemical and pharmaceutical purposes, and traditional and folk medicines. From ethnobotanical point of view, they have been recommended as effective tonic, sedative, diuretic and carminative remedies and extensively prescribed for the treatment of stomachache, inflammation, gastrointestinal, hemorrhoid, hay fever, and wound healing in indigenous medicines. They are also known as effective remedies that promote breast-feedings and regulate women menstruation. This review presents an overview on the ethnopharmacological knowledge of the Achillea genus and provides a deeper insight into medicinal and pharmaceutical applications of different Achillea species.