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      Acne fulminans associated with lymecycline intake: a case report

      case-report

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          Abstract

          Acne fulminans (AF) is a rare acne variant characterized by sudden onset of painful nodules on the face, chest, and back in the presence of systemic symptoms. Pharmacologic agents such as steroid hormones and isotretinoin are well-known triggers, and several cases have been described. We report a case of AF occurring a few days after lymecycline therapy initiation.

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          European evidence-based (S3) guideline for the treatment of acne - update 2016 - short version.

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            Beyond acne: Current aspects of sebaceous gland biology and function.

            The sebaceous gland is most commonly found in association with a hair follicle. Its traditional function is the holocrine production of sebum, a complex mixture of lipids, cell debris, and other rather poorly characterized substances. Due to the gland's central role in acne pathogenesis, early research had focused on its lipogenic activity. Less studied aspects of the sebaceous gland, such as stem cell biology, the regulation of cellular differentiation by transcription factors, the significance of specific lipid fractions, the endocrine and specially the neuroendocrine role of the sebaceous gland, and its contribution to the innate immunity, the detoxification of the skin, and skin aging have only recently attracted the attention of researchers from different disciplines. Here, we summarize recent multidisciplinary progress in sebaceous gland research and discuss how sebaceous gland research may stimulate the development of novel therapeutic strategies targeting specific molecular pathways of the pathogenesis of skin diseases.
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              Acne fulminans: report of clinical findings and treatment of twenty-four patients.

              Acne fulminans is an ulcerative form of acne with an acute onset and systemic symptoms. It most commonly affects adolescent boys.
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                Author and article information

                Journal
                Clin Cosmet Investig Dermatol
                Clin Cosmet Investig Dermatol
                Clinical, Cosmetic and Investigational Dermatology
                Clinical, Cosmetic and Investigational Dermatology
                Dove Medical Press
                1178-7015
                2018
                03 August 2018
                : 11
                : 403-405
                Affiliations
                Department of Dermatology, University of Pisa, Pisa, Italy, brunogualtieri86@ 123456gmail.com
                Author notes
                Correspondence: Bruno Gualtieri, Department of Dermatology, University of Pisa Via Roma 67, 56126 Pisa, Italy, Tel +39 32 9006 0388, Email brunogualtieri86@ 123456gmail.com
                Article
                ccid-11-403
                10.2147/CCID.S158925
                6082323
                1e48c6bd-d855-4243-86a9-8af31a900040
                © 2018 Gualtieri et al. This work is published and licensed by Dove Medical Press Limited

                The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

                History
                Categories
                Case Report

                Dermatology
                onset,systemic symptoms,steroids,trigger,isotretinoin,scars
                Dermatology
                onset, systemic symptoms, steroids, trigger, isotretinoin, scars

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