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      Selected Nutrients and Their Implications for Health and Disease across the Lifespan: A Roadmap

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          Abstract

          Worldwide approximately two billion people have a diet insufficient in micronutrients. Even in the developed world, an increasing number of people consume nutrient-poor food on a regular basis. Recent surveys in Western countries consistently indicate inadequate intake of nutrients such as vitamins and minerals, compared to recommendations. The International Osteoporosis Foundation’s (IOF) latest figures show that globally about 88% of the population does not have an optimal vitamin D status. The Lancet’s “Global Burden of Disease Study 2010” demonstrates a continued growth in life expectancy for populations around the world; however, the last decade of life is often disabled by the burden of partly preventable health issues. Compelling evidence suggests that improving nutrition protects health, prevents disability, boosts economic productivity and saves lives. Investments to improve nutrition make a positive contribution to long-term national and global health, economic productivity and stability, and societal resilience.

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          Most cited references59

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          Frailty in older adults: evidence for a phenotype

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            Comprehensive geriatric assessment for older adults admitted to hospital: meta-analysis of randomised controlled trials

            Objective To evaluate the effectiveness of comprehensive geriatric assessment in hospital for older adults admitted as an emergency. Search strategy We searched the EPOC Register, Cochrane’s Controlled Trials Register, the Database of Abstracts of Reviews of Effects (DARE), Medline, Embase, CINAHL, AARP Ageline, and handsearched high yield journals. Selection criteria Randomised controlled trials of comprehensive geriatric assessment (whether by mobile teams or in designated wards) compared with usual care. Comprehensive geriatric assessment is a multidimensional interdisciplinary diagnostic process used to determine the medical, psychological, and functional capabilities of a frail elderly person to develop a coordinated and integrated plan for treatment and long term follow-up. Data collection and analysis Three independent reviewers assessed eligibility and trial quality and extracted published data. Two additional reviewers moderated. Results Twenty two trials evaluating 10 315 participants in six countries were identified. For the primary outcome “living at home,” patients who underwent comprehensive geriatric assessment were more likely to be alive and in their own homes at the end of scheduled follow-up (odds ratio 1.16 (95% confidence interval 1.05 to 1.28; P=0.003; number needed to treat 33) at a median follow-up of 12 months versus 1.25 (1.11 to 1.42; P<0.001; number needed to treat 17) at a median follow-up of six months) compared with patients who received general medical care. In addition, patients were less likely to be living in residential care (0.78, 0.69 to 0.88; P<0.001). Subgroup interaction suggested differences between the subgroups “wards” and “teams” in favour of wards. Patients were also less likely to die or experience deterioration (0.76, 0.64 to 0.90; P=0.001) and were more likely to experience improved cognition (standardised mean difference 0.08, 0.01 to 0.15; P=0.02) in the comprehensive geriatric assessment group. Conclusions Comprehensive geriatric assessment increases patients’ likelihood of being alive and in their own homes after an emergency admission to hospital. This seems to be especially true for trials of wards designated for comprehensive geriatric assessment and is associated with a potential cost reduction compared with general medical care.
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              Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study.

              Seafood is the predominant source of omega-3 fatty acids, which are essential for optimum neural development. However, in the USA, women are advised to limit their seafood intake during pregnancy to 340 g per week. We used the Avon Longitudinal Study of Parents and Children (ALSPAC) to assess the possible benefits and hazards to a child's development of different levels of maternal seafood intake during pregnancy. 11,875 pregnant women completed a food frequency questionnaire assessing seafood consumption at 32 weeks' gestation. Multivariable logistic regression models including 28 potential confounders assessing social disadvantage, perinatal, and dietary items were used to compare developmental, behavioural, and cognitive outcomes of the children from age 6 months to 8 years in women consuming none, some (1-340 g per week), and >340 g per week. After adjustment, maternal seafood intake during pregnancy of less than 340 g per week was associated with increased risk of their children being in the lowest quartile for verbal intelligence quotient (IQ) (no seafood consumption, odds ratio [OR] 1.48, 95% CI 1.16-1.90; some, 1.09, 0.92-1.29; overall trend, p=0.004), compared with mothers who consumed more than 340 g per week. Low maternal seafood intake was also associated with increased risk of suboptimum outcomes for prosocial behaviour, fine motor, communication, and social development scores. For each outcome measure, the lower the intake of seafood during pregnancy, the higher the risk of suboptimum developmental outcome. Maternal seafood consumption of less than 340 g per week in pregnancy did not protect children from adverse outcomes; rather, we recorded beneficial effects on child development with maternal seafood intakes of more than 340 g per week, suggesting that advice to limit seafood consumption could actually be detrimental. These results show that risks from the loss of nutrients were greater than the risks of harm from exposure to trace contaminants in 340 g seafood eaten weekly.
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                Author and article information

                Journal
                Nutrients
                Nutrients
                nutrients
                Nutrients
                MDPI
                2072-6643
                22 December 2014
                December 2014
                : 6
                : 12
                : 6076-6094
                Affiliations
                [1 ]DSM Nutritional Products Ltd., Wurmisweg 576, 4303 Kaiseraugst, Switzerland; E-Mails: manfred.eggersdorfer@ 123456dsm.com (M.E.); peter.weber@ 123456dsm.com (P.W.)
                [2 ]University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands; E-Mails: e.buskens@ 123456umcg.nl (E.B.); f.kuipers@ 123456umcg.nl (F.K.)
                [3 ]Department of Geriatric Medicine, Medical Center Leeuwarden, Henri Dunantweg 2, 8934 AD Leeuwarden, The Netherlands; E-Mail: Dieneke.van.Asselt@ 123456ZNB.NL
                [4 ]Nestlé Research Centre, Vers-chez-les Blanc, 1000 Lausanne, Switzerland; E-Mail: patrick.detzel@ 123456rdls.nestle.com
                [5 ]Medical Department, Nutricia Advanced Medical Nutrition, Amsterdam, The Netherlands; E-Mail: karen.freyer@ 123456nutricia.com
                [6 ]Department of Public Health and Primary Care (CAPHRI), University of Maastricht, Universiteitssingel 40, 6229 ER Maastricht, The Netherlands
                [7 ]Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, 80337 Munich, Germany; E-Mail: Berthold.Koletzko@ 123456med.uni-muenchen.de
                [8 ]Sight and Life, Wurmisweg 576, 4303 Kaiseraugst, Switzerland; E-Mail: klaus.kraemer@ 123456dsm.com
                [9 ]Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St #5041, Baltimore, MD 21205, USA
                [10 ]Micronutrient Initiative, 180 Elgin Street, Suite 1000, K2P 2K3 Ottawa, Ontario, Canada; E-Mail: lneufeld@ 123456gainhealth.org
                [11 ]Aarhus Institute of Advanced Studies, University of Aarhus, Aarhus, Dk-8000, Denmark; E-Mail: rimaobeid@ 123456aias.au.dk
                [12 ]Winterthur Institute of Health Economics, Gertrudstrasse 15, 8401 Winterthur, Switzerland; E-Mail: simon.wieser@ 123456zhaw.ch
                [13 ]University of Bochum, Georgstraße 11, 32545 Bad Oeynhausen, Germany; E-Mail: azittermann@ 123456hdz-nrw.de
                [14 ]University of Bonn, Endenicher Allee 11-13, 53115 Bonn, Germany
                [15 ]University Hohenheim, Schloß Hohenheim 1, 70599 Stuttgart, Germany
                Author notes
                [†]

                These authors contributed equally to this work.

                [* ]Author to whom correspondence should be addressed; E-Mail: szabolcs.peter@ 123456dsm.com ; Tel.: +41-61-815-89-66; Fax: +41-61-815-80-50.
                Article
                nutrients-06-06076
                10.3390/nu6126076
                4277016
                25533014
                1e4c8a2e-d1e5-497a-a015-da5699ae1139
                © 2014 by the authors; licensee MDPI, Basel, Switzerland.

                This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 08 October 2014
                : 15 November 2014
                : 10 December 2014
                Categories
                Conference Report

                Nutrition & Dietetics
                healthy ageing,global health,nutrition economics,undernutrition
                Nutrition & Dietetics
                healthy ageing, global health, nutrition economics, undernutrition

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