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Origin and distribution of noradrenergic innervation in the habenula: A neurochemical study
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Abstract
The distribution of norepinephrine (NE) was chemically mapped in discrete regions
of the rat habenula (Hb). In addition, the contribution of both peripheral sympathetic
and central noradrenergic sources to habenula NE was quantified following selective
deafferentations. It was found that NE is distributed hetereogeneously in discrete
Hb regions. Furthermore, it was demonstrated that after superior cervical ganglionectomy
a small (26%) but significant (P less than 0.05) decrease in NE occurred only in the
medial Hb (MHb), while NE in the lateral Hb (LHb) remained unaltered. In contrast,
deafferentation of central noradrenergic innervation, such as lesions in the ascending
dorsal noradrenergic bundle (DNB), caused a marked decrease in NE in both MHb (53%)
and LHb (50%). Lesioning the dorsal longitudinal fasciculus resulted in NE loss in
both MHb and LHb by 31%. These data corroborate the histofluorescent demonstration
of the noradrenergic innervation of the Hb.