Chronic hepatitis B virus coinfection is associated with renal impairment among Zambian HIV-infected adults.

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Abstract

Among 6789 HIV-infected Zambian adults screened for hepatitis B virus (HBV) coinfection, estimated glomerular filtration rate (eGFR) was 50-90 mL/minute/1.73 m(2) in 17.6% and <50 mL/minute/1.73 m(2) in 2.5%. Human immunodeficiency virus/HBV coinfection was associated with eGFR <50 mL/minute/1.73 m(2) (adjusted odds ratio, 1.96 [95% confidence interval, 1.34-2.86]), adjusted for age, sex, CD4(+) count, and World Health Organization disease stage.

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Author and article information

Journal

Journal ID (iso-abbrev): Clin. Infect. Dis.

Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1537-6591

ISSN (Print): 1058-4838

Publication date (Electronic): Dec 15 2014

Volume: 59

Issue: 12

Affiliations

[1 ] Department of Medicine, University of Zambia University Teaching Hospital, Lusaka, Zambia.

[2 ] Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill Centre for Infectious Disease Research in Zambia, Lusaka.

[3 ] Department of Medicine, University of Zambia University Teaching Hospital, Lusaka, Zambia Centre for Infectious Disease Research in Zambia, Lusaka.

[4 ] Centre for Infectious Disease Research in Zambia, Lusaka Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill.

[5 ] Institute of Social and Preventive Medicine, University of Bern Department of Infectious Diseases, University Hospital Bern, Switzerland.

Article

Publisher Item ID: ciu734

DOI: 10.1093/cid/ciu734

PMC ID: 4311179

PubMed ID: 25228705

SO-VID: 1eae1c28-aa4e-4387-abd2-1cc3aeeb1d6b

History

Keywords: Africa,HIV/AIDS,hepatitis B virus,renal dysfunction,tenofovir

Data availability:

Keywords: Africa, HIV/AIDS, hepatitis B virus, renal dysfunction, tenofovir

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