Canadian case histories document the use of airborne and ground gamma‐ray spectrometry to detect and map potassium alteration associated with different styles of mineralization. These include: volcanic‐hosted massive sulfides (Cu‐Pb‐Zn), Pilley’s Island, Newfoundland; polymetallic, magmatic‐hydrothermal deposits (Au‐Co‐Cu‐Bi‐W‐As), Lou Lake, Northwest Territories; and porphyry Cu‐Au‐(Mo) deposits at Mt. Milligan, British Columbia and Casino, Yukon Territory. Mineralization in two of these areas was discovered using airborne gamma‐ray spectrometry. In each case history, alteration produces potassium anomalies that can be distinguished from normal lithologic potassium variations by characteristic lows in eTh/K ratios. Interpretations incorporating airborne and ground spectrometry, surficial and bedrock geochemistry and petrology show that gamma‐ray spectrometric patterns provide powerful guides to mineralization. This information complements magnetic, electromagnetic, geological, and conventional geochemical data commonly gathered during mineral exploration programs.