Comportamiento del hierro sérico y la inmunidad celular en ancianos institucionalizados en el hogar "Santovenia"

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Abstract

Introducción: relacionado con el estado nutricional, el hierro (Fe) es un nutriente esencial para la mayor parte de los tejidos. Objetivo: relacionar la anemia por déficit de hierro con la inmunidad celular en adultos mayores institucionalizados en el hogar de ancianos «Santovenia». Métodos: se realizó un estudio en 41 individuos mayores de 60 años de edad procedentes del hogar de ancianos «Santovenia», 21 portadores de anemia por déficit de hierro y 20 controles normales, a los cuales se les determinó la concentración de hemoglobina (Hb), hematocrito (Hto), hierro sérico (Fe), y se les realizó estudio de la inmunidad celular, roseta activa y roseta espontánea. Resultados: se compararon los resultados del grupo control con los del grupo muestra, para estas variables. Se realizó un estudio estadístico por el test T de Student de comparación de medias, y los resultados fueron una disminución de Hb, Hto, hierro sérico y de la roseta activa y roseta espontánea en el grupo muestra con relación al control, con una diferencia significativa para a = 0,01. Conclusiones: los ancianos que presentaban los valores de Hb más bajos (£ 9), tenían valores de Fe disminuido y la inmunidad celular afectada.

Translated abstract

Introduction: Related to nutritional status, iron (Fe) is an essential nutrient for most of tissues. Objective: To relate the iron-deficiency anemia with the cellular immunity in elderlies institutionalized in "Santovenia" old people home. Methods: Authors conducted a study in 41 subjects aged over 60 from the above mentioned old people home, 21 had iron-deficiency anemia and 20 normal controls, in which we determined the hemoglobin (Hb), hematocrit (Hto), and serum iron (Fe) concentrations and also a cellular immunity study, active and spontaneous rosettes. Results: For these variables, results from control and sample group were compared. A statistical study was conducted by Student T test of means comparisons, and results showed a decrease of Hb, Hto, serum iron and active and spontaneous rosettes in sample group related to control one with a significant difference for a = 0,01. Conclusions: Elderlies with the lowest values of Hb (£ 9) had Fe values decreased and affectation of cellular immunity.

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Most cited references 21

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Improved direct specific determination of serum iron and total iron-binding capacity.

F Ceriotti, G Ceriotti (1980)

Serum iron is released from transferrin and reduced at pH 1.7 by treating serum with a 10 g/L ascorbic acid solution in 0.1 mol/L HCl. When ferrozine is added to this reagent, it forms a complex with iron that is as intensely colored as at higher pH values, and under these conditions no turbidity is produced. The second major interference, that from copper, is eliminated by adding 1 g of thiosemicarbazide per liter, which at a low pH forms a stable, uncolored complex with copper without affecting the reaction of ferrozine with iron.