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      Longevity expectations in the pension fund, insurance, and employee benefits industries

      research-article
      Psychology Research and Behavior Management
      Dove Medical Press
      life expectancy, gerontology, actuarial, retirement, beliefs

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          Abstract

          Considerable progress has been made in many areas of biomedical science since the 1960s, suggesting likely increases in life expectancy and decreases in morbidity and mortality in the adult population. These changes may pose substantial risks to the pensions and benefits industries. While there is no significant statistical evidence demonstrating rapid decreases in mortality rates, there are conflicting opinions among demographers and biogerontologists on the biological limits of the human lifespan and trends in life expectancy. We administered a survey of the International Employee Benefits Association (IEBA), a large, international industry group. Industry professionals employed by consulting (35%), insurance (24%), pension (14%), and other (27%) companies responded to 32 questions. Respondents showed reasonably conservative views on the future of longevity and retirement, including that for women. The respondents formed their personal longevity expectations based on their family history and, to a lesser degree, on the actuarial life tables. Most of the sample expressed no desire to life past age 100 years, even if the enabling technologies required to maintain a healthy youthful state were available, and only a few respondents in the sample expressed a desire to live for the maximum period (at least) offered by the survey question. The majority of the respondents would not undergo any invasive procedures, and only 56% of the respondents would opt for noninvasive therapies to extend their healthy lifespans to 150 years of age if these were available.

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          Most cited references30

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          Demography. Broken limits to life expectancy.

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            Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

            A major goal in aging research is to improve health during aging. In the case of mice, genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased or increased longevity. Based on this, we have tested the effects of a telomerase gene therapy in adult (1 year of age) and old (2 years of age) mice. Treatment of 1- and 2-year old mice with an adeno associated virus (AAV) of wide tropism expressing mouse TERT had remarkable beneficial effects on health and fitness, including insulin sensitivity, osteoporosis, neuromuscular coordination and several molecular biomarkers of aging. Importantly, telomerase-treated mice did not develop more cancer than their control littermates, suggesting that the known tumorigenic activity of telomerase is severely decreased when expressed in adult or old organisms using AAV vectors. Finally, telomerase-treated mice, both at 1-year and at 2-year of age, had an increase in median lifespan of 24 and 13%, respectively. These beneficial effects were not observed with a catalytically inactive TERT, demonstrating that they require telomerase activity. Together, these results constitute a proof-of-principle of a role of TERT in delaying physiological aging and extending longevity in normal mice through a telomerase-based treatment, and demonstrate the feasibility of anti-aging gene therapy.
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              Overweight and obesity: prevalence, consequences, and causes of a growing public health problem.

              This paper provides an overview of the evidence on the current epidemic of obesity in the United States. The prevalence of overweight and obesity now exceeds 60% among US adults, and the rate is rapidly increasing among children and adolescents. Dismal medical, social, and economic consequences are already apparent and likely to worsen without multipronged intervention. Increased rates of hypertension, diabetes, and dyslipidemia, among other medical conditions, threaten to shorten the longevity of the American populace by as much as 5 years. The incidence of depression is increasing and experts suggest this is linked with the increased prevalence of obesity. The cost of obesity-related medical care has increased astronomically since 1987, in addition to lost productivity and income. Novel multidisciplinary, preventive, and therapeutic approaches, and social changes are needed that address the complex interplay of biologic, genetic, and social factors that have created the current obesity epidemic.
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                Author and article information

                Journal
                Psychol Res Behav Manag
                Psychol Res Behav Manag
                Psychology Research and Behavior Management
                Psychology Research and Behavior Management
                Dove Medical Press
                1179-1578
                2015
                20 January 2015
                : 8
                : 27-39
                Affiliations
                Biogerontology Research Foundation, London, United Kingdom
                Author notes
                Correspondence: Alex Zhavoronkov, Biogerontology Research Foundation, 4 Hill Street, London, W1J 5NE, United Kingdom, Tel +44 7578 66 9995, Email alex@ 123456biogerontology.org
                Article
                prbm-8-027
                10.2147/PRBM.S75440
                4309776
                25653568
                1ef8566c-b7d2-4562-98bb-3537f72ce371
                © 2015 Zhavoronkov. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

                The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

                History
                Categories
                Original Research

                Clinical Psychology & Psychiatry
                life expectancy,gerontology,actuarial,retirement,beliefs
                Clinical Psychology & Psychiatry
                life expectancy, gerontology, actuarial, retirement, beliefs

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