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      Maternal pelvic size, fetal growth and risk of stroke in adult offspring in a large Swedish cohort.

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          Abstract

          Earlier research suggests that maternal pelvic size is associated with offspring's stroke risk in later life. We followed 6362 men and women from Uppsala, Sweden, born between 1915 and 1929 from 1964 to 2008 to assess whether maternal pelvic size was associated with incidence of thrombotic stroke (TS), haemorrhagic stroke (HS) and other stroke (OS). Offspring whose mothers had a flat pelvis had lower birth weight and birth-weight-for-gestational-age compared with those who did not. Inverse linear associations of birth-weight-for-gestational-age were observed with TS and OS. Female offspring whose mothers had a flat pelvis had increased risk of TS, but flat pelvis was not associated with other types of stroke. A smaller difference between intercristal and interspinous diameters and a smaller external conjugate diameter were independently associated with HS, whereas no pelvic measurements were associated with OS. We conclude that a smaller pelvis in women may impact the health of their offspring in adulthood.

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          Author and article information

          Journal
          J Dev Orig Health Dis
          Journal of developmental origins of health and disease
          Cambridge University Press (CUP)
          2040-1752
          2040-1744
          Feb 2016
          : 7
          : 1
          Affiliations
          [1 ] 1Centre for Health Equity Studies (CHESS),Stockholm University/Karolinska Institutet,Stockholm,Sweden.
          Article
          S2040174415007254
          10.1017/S2040174415007254
          26441399
          1fb10b82-6122-410b-a0db-30d613454954
          History

          fetal growth,pelvic size,stroke,childhood social class
          fetal growth, pelvic size, stroke, childhood social class

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