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Abstract
Chemotherapy is an important method in the treatment of cervical cancer, but some
patients will face drug resistance, which often indicates a poor prognosis. Moreover,
there is no complete solution at present. Therefore, it is urgent to study the drug
resistance mechanism of cervical cancer. Based on sequencing data mining, we predicted
that MBNL1 might be involved in the occurrence and poor prognosis of cervical cancer,
and verifed that MBNL1 could regulate the resistance of HeLa cells to cisplatin via
Nrf2. In addition, we demonstrated that MBNL1 up regulated the degradation of Nrf2
protein by increasing the mRNA stability of Cul3. These results can provide theoretical
basis for clinical development of new diagnosis and treatment targets for cisplatin
resistance.