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      Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical network model.

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          Abstract

          Single-neuron recordings from behaving primates have established a link between working memory processes and information-specific neuronal persistent activity in the prefrontal cortex. Using a network model endowed with a columnar architecture and based on the physiological properties of cortical neurons and synapses, we have examined the synaptic mechanisms of selective persistent activity underlying spatial working memory in the prefrontal cortex. Our model reproduces the phenomenology of the oculomotor delayed-response experiment of Funahashi et al. (S. Funahashi, C.J. Bruce and P.S. Goldman-Rakic, Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. J Neurophysiol 61:331-349, 1989). To observe stable spontaneous and persistent activity, we find that recurrent synaptic excitation should be primarily mediated by NMDA receptors, and that overall recurrent synaptic interactions should be dominated by inhibition. Isodirectional tuning of adjacent pyramidal cells and interneurons can be accounted for by a structured pyramid-to-interneuron connectivity. Robust memory storage against random drift of the tuned persistent activity and against distractors (intervening stimuli during the delay period) may be enhanced by neuromodulation of recurrent synapses. Experimentally testable predictions concerning the neural basis of working memory are discussed.

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          Author and article information

          Journal
          Cereb Cortex
          Cerebral cortex (New York, N.Y. : 1991)
          Oxford University Press (OUP)
          1047-3211
          1047-3211
          Sep 2000
          : 10
          : 9
          Affiliations
          [1 ] Volen Center for Complex Systems, Brandeis University, Waltham, MA 02254, USA.
          Article
          10.1093/cercor/10.9.910
          10982751
          1fee820a-f8bd-41bc-b5c4-45e9f018d2b7
          History

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