Antidepressant-like Effects of Electroconvulsive Seizures Require Adult Neurogenesis in a Neuroendocrine Model of Depression.

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Abstract

Neurogenesis continues throughout life in the hippocampal dentate gyrus. Chronic treatment with monoaminergic antidepressant drugs stimulates hippocampal neurogenesis, and new neurons are required for some antidepressant-like behaviors. Electroconvulsive seizures (ECS), a laboratory model of electroconvulsive therapy (ECT), robustly stimulate hippocampal neurogenesis.

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Journal

Journal ID (iso-abbrev): Brain Stimul

Title: Brain stimulation

Publisher: Elsevier BV

ISSN (Electronic): 1876-4754

ISSN (Print): 1876-4754

Publication date (Electronic): July 4 2015

Volume: 8

Issue: 5

Affiliations

[1 ] University of Maryland School of Medicine, Department of Psychiatry, Baltimore, MD, USA; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.

[2 ] Université Paris Sud, INSERM UMR S 1178, Faculté de Pharmacie, Châtenay-Malabry, France.

[3 ] Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.

[4 ] Global Therapeutic Area Head, Neuroscience, Janssen Research & Development, Titusville, NJ, USA.

[5 ] Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Departments of Psychiatry and Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: keri.martinowich@libd.org.

Article

Publisher Item ID: S1935-861X(15)00966-3 Mid ID: NIHMS706493

DOI: 10.1016/j.brs.2015.05.011

PMC ID: 4567930

PubMed ID: 26138027

SO-VID: 202c056b-037d-43da-8e62-dd6065cc28bf

History

Keywords: ECS,Hippocampus,Neurogenesis,Neuroplasticity,Antidepressant,ECT

Data availability:

Keywords: ECS, Hippocampus, Neurogenesis, Neuroplasticity, Antidepressant, ECT

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