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      Prevalence and Impact of obesity on fibromyalgia syndrome and its allied symptoms

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          A BSTRACT

          Background:

          Fibromyalgia syndrome (FMS) is a commonly occurring and disabling chronic pain disorder of unknown etiology. It is a syndrome of widespread diffuse pain with a low pain threshold and different FMS allied symptoms. Obesity is a comorbidity that is commonly occurring with FMS and may be linked to its severity. This study aims to estimate the prevalence of overweight and obesity in FMS and their effect on pain and FMS allied symptoms.

          Methods:

          One hundred and ten (10 male and 100 female) FMS patients diagnosed following the 1990 American College of Rheumatology (ACR) classification criteria for FMS completed a questionnaire about age, gender, and pain severity on a visual analog scale (VAS), evaluated for morning stiffness, disturbance of sleep, fatigue, anxiety, depression, and irritable bowel and the count of tender points. Weight, height, and body mass index (BMI) were calculated for all participants.

          Results:

          Seventy-four (67.27%) were overweight/obese; of them, 68 (61.81%) were females. All the FMS allied symptoms were more prevalent in overweight/obese FMS patients. Overweight/obese FMS patients have a high number of TP and greater pain sensitivity to TP palpation.

          Conclusion:

          Overweight and obesity are commonly associated with FMS. Obesity may contribute to the severity of FMS and its allied symptoms.

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          Most cited references44

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          The american college of rheumatology 1990 criteria for the classification of fibromyalgia

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            A comparison of pain measurement characteristics of mechanical visual analogue and simple numerical rating scales.

            Numerical rating scales and mechanical visual analogue scales (M-VAS) were compared for their capacity to provide ratio scale measures of experimental pain. Separate estimates of experimental pain sensation intensity and pain unpleasantness were obtained by each method, as were estimates of clinical pain. Orofacial pain patients made numerical scale and VAS ratings in response to noxious thermal stimuli (45-51 degrees C) applied for 5 sec to the forearm by a contact thermode. The derived stimulus-response function was well fit as a power function only in the case of sensory M-VAS. The power function derived from sensory M-VAS ratings predicted temperatures chosen as twice as intense as standard temperatures of 47 degrees C and 48 degrees C, thereby providing evidence for ratio scale characteristics of M-VAS. The stimulus-response function derived from sensory numerical ratings differed from that obtained with M-VAS and did not provide accurate predictions of temperatures perceived as twice intense at 47 degrees C or 48 degrees C. Both M-VAS and numerical rating scales produced reliably different stimulus response functions for pain sensation intensity as compared to pain unpleasantness and both provided consistent measures of experimental and clinical pain intensity. Finally, both mechanical and pencil-and-paper VAS produced very similar stimulus-response functions. The ratio scale properties of M-VAS combined with its ease of administration and scoring in clinical settings offer the possibility of a simple yet powerful pain measurement technology in both research and health care settings.
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              Neurobiology of fibromyalgia and chronic widespread pain

              Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified. The underlying mechanisms, in both human and animal studies, for the continued pain in individuals with fibromyalgia will be explored in this review. There is a substantial amount of support for alterations of central nervous system nociceptive processing in people with fibromyalgia, and that psychological factors such as stress can enhance the pain experience. Emerging evidence has begun exploring other potential mechanisms including a peripheral nervous system component to the generation of pain and the role of systemic inflammation. We will explore the data and neurobiology related to the role of the CNS in nociceptive processing, followed by a short review of studies examining potential peripheral nervous system changes and cytokine involvement. We will not only explore the data from human subjects with fibromyalgia but will relate this to findings from animal models of fibromyalgia. We conclude that fibromyalgia and related disorders are heterogenous conditions with a complicated pathobiology with patients falling along a continuum with one end a purely peripherally driven painful condition and the other end of the continuum is when pain is purely centrally driven.
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                Author and article information

                Journal
                J Family Med Prim Care
                J Family Med Prim Care
                JFMPC
                J Family Med Prim Care
                Journal of Family Medicine and Primary Care
                Wolters Kluwer - Medknow (India )
                2249-4863
                2278-7135
                January 2023
                15 February 2023
                : 12
                : 1
                : 123-127
                Affiliations
                [1] Higher Diploma in Rheumatology, Rheumatology Unit in Basrah Teaching Hospital Basrah, Iraq
                Author notes
                Address for correspondence: Dr. Abdulsatar J. Mathkhor, Rheumatology Unit in Basrah Teaching Hospital Basrah, Iraq. E-mail: amathkhoor@ 123456yahoo.co.uk
                Article
                JFMPC-12-123
                10.4103/jfmpc.jfmpc_2052_22
                10071906
                37025232
                2039ed74-2031-4fb1-b668-20904b420293
                Copyright: © 2023 Journal of Family Medicine and Primary Care

                This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

                History
                : 20 October 2022
                : 01 December 2022
                : 09 December 2022
                Categories
                Original Article

                fibromyalgia,obesity,overweight,pain
                fibromyalgia, obesity, overweight, pain

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