Jeanette M. Metzger: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Project administrationRole: SoftwareRole: ValidationRole: VisualizationRole:
Writing – original draftRole: Writing – review & editing
Helen N. Matsoff: Role: InvestigationRole: VisualizationRole: Writing – review & editing
Alexandra D. Zinnen: Role: InvestigationRole: MethodologyRole: VisualizationRole: Writing – review & editing
Rachel A. Fleddermann: Role: InvestigationRole: VisualizationRole: Writing – review & editing
Viktoriya Bondarenko: Role: InvestigationRole: MethodologyRole: Project administrationRole: ValidationRole:
Writing – review & editing
Heather A. Simmons: Role: InvestigationRole: Writing – review & editing
Andres Mejia: Role: InvestigationRole: Writing – review & editing
Colleen F. Moore: Role: Formal analysisRole: InvestigationRole: MethodologyRole: SoftwareRole: Writing
– review & editing
Marina E. Emborg:
ORCID: http://orcid.org/0000-0002-9351-6641
Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole:
Writing – original draftRole: Writing – review & editing
Michael Bader: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
7
January
2020
Publication date Collection: 2020
Volume: 15
Issue: 1
Electronic Location Identifier: e0226999
Affiliations
[1
]
Wisconsin National Primate Research Center, University of Wisconsin–Madison, Madison,
WI, United States of America
[2
]
Cellular and Molecular Pathology Graduate Program, University of Wisconsin–Madison,
Madison, WI, United States of America
[3
]
Department of Psychology, University of Wisconsin–Madison, Madison, WI, United States
of America
[4
]
Department of Medical Physics, University of Wisconsin–Madison, Madison, WI, United
States of America
Max Delbruck Centrum fur Molekulare Medizin Berlin Buch, GERMANY
Author notes
Competing Interests: The authors have declared that no competing interests exist.
[¤]
Current address: School of Medicine, The University of New Mexico, Albuquerque, NM,
United States of America
Author information
Article
Publisher ID:
PONE-D-19-17539
DOI: 10.1371/journal.pone.0226999
PMC ID: 6946159
PubMed ID: 31910209
SO-VID: 20adeb03-ff6c-4a7a-801d-7aa4c77d98ee
Copyright © © 2020 Metzger et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: P51OD011106
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: R21NS084158
Award Recipient
:
ORCID: http://orcid.org/0000-0002-9351-6641
Marina E. Emborg
Funded by: funder-id http://dx.doi.org/10.13039/100000050, National Heart, Lung, and Blood Institute;
Award ID: F31HL136047
Award Recipient
:
Jeanette M. Metzger
Funded by: College of Letters and Sciences, University of Wisconsin–Madison
Award ID: Welton L&S Honors Sophomore Scholarship
Award Recipient
:
Rachel A. Fleddermann
Funded by: College of Letters and Sciences, University of Wisconsin–Madison
Award ID: Trewartha Undergraduate Honors Research Grant
Award Recipient
:
Rachel A. Fleddermann
Funded by: funder-id http://dx.doi.org/10.13039/100000040, American Parkinson's Disease Foundation;
Award ID: PF-APDA-SFW-1854
Award Recipient
:
Helen N. Matsoff
This study was supported by NIH P51OD011106 (
nih.gov), NIH R21NS084158 [MEE] (
nih.gov), NIH Kirschstein-NRSA F31HL136047 [JMM] (
nih.gov), Welton L&S Honors Sophomore Scholarship [RAF] (
honors.ls.wisc.edu), Trewartha Undergraduate Honors Research Grant [R.A.F] (
honors.ls.wisc.edu), PF-APDA-SFW-1854 [HNM] (
apdaparkinson.org), and the University of Wisconsin–Madison Office of Vice Chancellor for Research
and Graduate Education (
research.wisc.edu), Cellular and Molecular Pathology Graduate Program (
cmp.wisc.edu), and Department of Medical Physics (
medphysics.wisc.edu). The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Neurons
Subject:
Nerve Fibers
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Cellular Neuroscience
Subject:
Neurons
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Nerve Fibers
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
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Animal Cells
Subject:
Muscle Cells
Subject:
Cardiomyocytes
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Biology and Life Sciences
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Anatomy
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Biological Tissue
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Muscle Tissue
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Muscle Cells
Subject:
Cardiomyocytes
Subject:
Medicine and Health Sciences
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Anatomy
Subject:
Biological Tissue
Subject:
Muscle Tissue
Subject:
Muscle Cells
Subject:
Cardiomyocytes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
Subject:
Cardiac Ventricles
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
Subject:
Cardiac Ventricles
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
Subject:
Research and Analysis Methods
Subject:
Imaging Techniques
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Neuroimaging
Subject:
Positron Emission Tomography
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Neuroimaging
Subject:
Positron Emission Tomography
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Diagnostic Radiology
Subject:
Tomography
Subject:
Positron Emission Tomography
Subject:
Research and Analysis Methods
Subject:
Imaging Techniques
Subject:
Diagnostic Radiology
Subject:
Tomography
Subject:
Positron Emission Tomography
Subject:
Medicine and Health Sciences
Subject:
Radiology and Imaging
Subject:
Diagnostic Radiology
Subject:
Tomography
Subject:
Positron Emission Tomography
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Oxidative Stress
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Neurology
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Neurodegenerative Diseases
Subject:
Movement Disorders
Subject:
Parkinson Disease